Increased expressions of MMP-2 and MMP-9 in lung following 12 Gy local irradiation

Name: Work Video:
Duration: 3 min 30 s
杨坤禹; LIU Li; 张 涛; 胡豫; C. Ruebe; Ruebe Christian; 伍钢
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'https://openalex.org/W3030868230', 'https://openalex.org/W3030692868', 'https://openalex.org/W3030442061', 'https://openalex.org/W3030333496', 'https://openalex.org/W3030168805', 'https://openalex.org/W3030112887', 'https://openalex.org/W3029779073', 'https://openalex.org/W3029645180', 'https://openalex.org/W3029163938', 'https://openalex.org/W3029095879', 'https://openalex.org/W3029033512'], 'abstract_inverted_index': {'目的': [0], '通过检测基质金属蛋白酶(MMPs)和基质金属蛋白酶组织抑制物(TIMPs)在单次大剂量胸部照射小鼠肺组织中的表达,探讨全肺照射诱导的MMPs/TIMPs系统表达紊乱在放射性肺损伤发生与发展中的作用.方法': [1], '实验组小鼠在出生后8周时给予单次胸部照射12': [2], 'Gy,对照组小鼠给予假照射.在照射后4和8周时处死小鼠,收集肺组织标本,测定肺组织中MMP-2、MMP-9、MMP-3、MMP-13、TIMP-1、TIMP-2和TIMP-3蛋白的表达.结果': [3], '照射后4和8周时,实验组小鼠肺组织中MMP-2表达水平分别为对照组的1.7和1.9倍,MMP-9表达水平分别为对照组的2.7和2.6倍,而MMP-3、MMP-13、TIMP-1、TIMP-2、和TIMP-3的表达水平与对照组比较无显著改变.结论': [4], '辐射诱导小鼠肺组织中MMP-2和MMP-9的表达增加,可能加剧了急性放射性肺损伤。': [5]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029118630', 'counts_by_year': [], 'updated_date': '2024-12-06T10:36:23.370910', 'created_date': '2020-06-05'}
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