Publication Information

{'id': 'https://openalex.org/W3032437214', 'doi': 'https://doi.org/10.3760/cma.j.issn.1006-4443.2004.08.029', 'title': 'Expression of MMP- 1 and its inhibitor in alkali-burned rat cornea', 'display_name': 'Expression of MMP- 1 and its inhibitor in alkali-burned rat cornea', 'publication_year': 2004, 'publication_date': '2004-08-10', 'ids': {'openalex': 'https://openalex.org/W3032437214', 'doi': 'https://doi.org/10.3760/cma.j.issn.1006-4443.2004.08.029', 'mag': '3032437214'}, 'language': 'ko', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN211348200408/318246.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764931669', 'display_name': 'Chinese Journal of Practical Ophthalmology', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': 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['https://openalex.org/W3032694421', 'https://openalex.org/W3032675685', 'https://openalex.org/W3031958728', 'https://openalex.org/W3031872621', 'https://openalex.org/W3031534618', 'https://openalex.org/W3031505833', 'https://openalex.org/W3031449654', 'https://openalex.org/W3031441417', 'https://openalex.org/W3031346570', 'https://openalex.org/W3030868230', 'https://openalex.org/W3030692868', 'https://openalex.org/W3030442061', 'https://openalex.org/W3030168805', 'https://openalex.org/W3030112887', 'https://openalex.org/W3029779073', 'https://openalex.org/W3029645180', 'https://openalex.org/W3029118630', 'https://openalex.org/W3029095879', 'https://openalex.org/W3029033512', 'https://openalex.org/W2976592231'], 'abstract_inverted_index': {'目的': [0], '探讨碱烧伤后不同时期基质金属蛋白酶-1(MMP-1)及其组织型抑制剂(TIMP-1)的表达及作用.方法建立大鼠角膜碱烧伤模型,应用免疫组化方法检测MMP-1及TIMP-1在碱烧伤后不同时期角膜内的表达.结果免疫组化显示:正常大鼠角膜组织中无MMP-1及其抑制剂的表达.实验组MMP-1于伤后第1天开始升高,14天达到最高,此后呈现下降趋势,但仍高于正常对照组.而TIMP-1早期有所表达,而后活性逐渐下降,伤后第14天降至最低水平,此后又再度上升,21天时达到最高.结论角膜溶解高峰期出现于碱烧伤后第14天.此时MMP-1分泌达高峰,TIMP-1分泌达到最低点.角膜溶解的临床病理过程与MMP-1及TIMP-1的分泌密切相关。': [1]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3032437214', 'counts_by_year': [], 'updated_date': '2024-12-14T01:25:41.975989', 'created_date': '2020-06-05'}