Expressions of MMP-2 and TIMP-2 in pituitary adenomas and the significance of their expressions

Name: Work Video:
Duration: 3 min 30 s
李玉斌; 魏新亭; 宋来君; 程敬亮; 冯继; 刘运生
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'display_name': 'Matrix metalloproteinase', 'level': 2, 'score': 0.66764915}, {'id': 'https://openalex.org/C2779318953', 'wikidata': 'https://www.wikidata.org/wiki/Q864296', 'display_name': 'Pituitary adenoma', 'level': 3, 'score': 0.43447113}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3516978}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.32806027}, {'id': 'https://openalex.org/C2777428134', 'wikidata': 'https://www.wikidata.org/wiki/Q272741', 'display_name': 'Adenoma', 'level': 2, 'score': 0.21811181}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN11535420070609/467140.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764375915', 'display_name': 'Chinese Journal of Neuromedicine', 'issn_l': None, 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'https://openalex.org/W3030168805', 'https://openalex.org/W3030112887', 'https://openalex.org/W3029779073', 'https://openalex.org/W3029645180', 'https://openalex.org/W3029387481', 'https://openalex.org/W3029118630', 'https://openalex.org/W3029095879', 'https://openalex.org/W3029033512', 'https://openalex.org/W2976592231', 'https://openalex.org/W2603215685'], 'abstract_inverted_index': {'目的': [0], '探讨基质金属蛋白酶(MMP)-2及其组织抑制因子(TIMP)-2的蛋白表达与垂体腺瘤侵袭性的关系.方法': [1], '采用免疫组化SP法检测8例正常垂体前叶组织、20例非侵袭性和31例侵袭性垂体腺瘤组织中MMP-2和TIMP-2的蛋白表达.结果': [2], '在正常垂体前叶组织、非侵袭性垂体腺瘤和侵袭性垂体腺瘤中MMP-2的阳性表达率分别为62.5%(5/8)、80%(16/20)和87.1%(27/31),TIMP-2的阳性表达率分别为100%(8/8)、80%(16/20)和38.7%(12/31).在非侵袭性垂体腺瘤中MMP-2和TIMP-2表达强度差别无统计学意义(P＞0.05),在侵袭性垂体腺瘤中二者差别有统计学意义(P＜0.05).结论': [3], '垂体腺瘤的侵袭性与MMP-2和TIMP-2的表达失衡密切相关,二者可能在调控垂体腺瘤的侵袭性生长过程中起重要的作用。': [4]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029163938', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-10T23:45:59.796358', 'created_date': '2020-06-05'}
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