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'https://openalex.org/W2976592231', 'https://openalex.org/W2603215685'], 'abstract_inverted_index': {'目的': [0], '研究MMP-9和TIMP-1在膀胱癌中的表达情况,探讨其表达失衡与膀胱癌转移和预后的关系.方法': [1], '应用S-P免疫组化法,检测86例膀胱癌MMP-9和TIMP-1表达情况,并行回顾性随访.结果': [2], '在68例膀胱癌组中,MMP-9、TIMP-2阳性表达率分别为63.95%、59.30%.MMP-9阳性表达率随着肿瘤病理分级、浸润深度、淋巴结转移、TNM分期的升高而增加,而TIMP-1阳性表达率则呈下降趋势(p＜0.05).MMP-9表达超过TIMP-1者膀胱癌发生肌层浸润、淋巴结转移的比例明显高于TIMP-1表达超过MMP-9者或二者表达平衡者,而MMP-9表达超过TIMP-1者生存率明显低于TIMP-1表达超过MMP-9者(p＜0.05).结论': [3], 'MMP-9以促进肿瘤浸润转移为主,TIMP-1对膀胱癌有独立的抑制作用,MMP-9阳性表达而TIMP-1阴性表达者则其膀胱癌预后不良.MMP-9、TIMP-1表达可作为判断膀胱癌生物学行为和预后的重要指标。': [4]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3030868230', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-13T16:58:17.388568', 'created_date': '2020-06-05'}