Analysis of the expression of matrix metalloproteinase and tissue inhibitor of metalloproteinase in gestational trophoblastic diseases

Name: Work Video:
Duration: 3 min 30 s
戴淑真; 王灵芝; 李玉军
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'探讨基质金属蛋白酶(MMP)及其抑制物(TIMP)在妊娠滋养细胞疾病中的表达水平与其侵袭程度的关系.方法': [1], '采用免疫组织化学PV-6000法测定49例葡萄胎(其中8例发生恶变,为葡萄胎恶变组;另外41例为葡萄胎未恶变组)、6例侵蚀性葡萄胎(侵蚀性葡萄胎组)、2例绒毛膜癌(绒毛膜癌组)和18例正常早孕绒毛组织(正常绒毛组)的MMP-7、MMP-9、TIMP-1、TIMP-2的表达及分布情况.结果': [2], 'MMP-7、MMP-9、TIMP-2、MMP-9/TIMP-1值在绒毛膜癌、侵蚀性葡萄胎及葡萄胎恶变组中的表达分别高于正常绒毛和葡萄胎未恶变组(F=10.950,7.760,7.304,3.442;P均＜0.05);MMP-7、MMP-9、TIMP-1、TIMP-2表达在正常绒毛和葡萄胎未恶变组之间差异均无统计学意义.结论': [3], 'MMP和TIMP表达水平的高低与妊娠滋养细胞疾病的侵袭程度有关。': [4]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3030168805', 'counts_by_year': [], 'updated_date': '2024-12-14T14:55:12.072373', 'created_date': '2020-06-05'}
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