Publication Information

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'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.16522709}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN431274200802/275243.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306541551', 'display_name': '中国医师杂志', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032564753', 'https://openalex.org/W3032209312', 'https://openalex.org/W3032101686', 'https://openalex.org/W3031905214', 'https://openalex.org/W3031872621', 'https://openalex.org/W3031624437', 'https://openalex.org/W3031441417', 'https://openalex.org/W3031217498', 'https://openalex.org/W3030692868', 'https://openalex.org/W3030220879', 'https://openalex.org/W3030015305', 'https://openalex.org/W3029779073', 'https://openalex.org/W3029697296', 'https://openalex.org/W3029645180', 'https://openalex.org/W3029578110', 'https://openalex.org/W3029347836', 'https://openalex.org/W3028623734', 'https://openalex.org/W2876226555', 'https://openalex.org/W2756768910', 'https://openalex.org/W2739682962'], 'abstract_inverted_index': {'目的': [0], '研究基质金属蛋白酶(MMPs),MMP-2,MMP-9,MMP-14和组织基质金属蛋白酶抑制剂(TIMP)与早期类风湿关节炎患者X线侵蚀改变的关系.方法': [1], '募集66例早期滑膜炎患者为研究对象.采用酶法测定血清MMP-1,MMP-2,MMP-9,MMP-14和TIMP-1,TIMP-2的水平,用免疫组化法测定滑膜组织MMP-2,MMP-9及其分子调节剂的表达水平.用明胶酶谱法测定MMP-2,MMP-9的活力.4例健康对照组也进行相应检测.结果': [2], 'RA患者组织MMP-14(MMP-2酶原激活剂)表达明显强于非RA患者[(8.4±5)vs(3.7±4)cells/HPF,P＜0.01)].相反,RA患者中TIMP-2(MMP-2抑制剂)表达低于非RA患者[(25±12)vs(39±9)cells/HPF,P＜0.01)].正常滑膜组织未检测到MMP-2,MMP-14和TIMP-2的表达.滑膜组织侵蚀改变患者MMP-2明显高于非侵蚀性改变者.但MMP-2与MMP-9的组织表达与血清表达不相关.结论': [3], 'MMP-2,MMP-9在RA患者的关节侵蚀性改变进展过程中产生重要作用.推测通过抑制MMP-2和MMP-9活性的治疗策略可延缓或预防关节滑膜的早期侵蚀性改变。': [4]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3032752798', 'counts_by_year': [], 'updated_date': '2024-12-11T00:16:32.028320', 'created_date': '2020-06-05'}