Publication Information

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{'目的检测基质金属蛋白酶MMP-2、-9及其抑制剂TIMP-2、-1在不同分期神经母细胞瘤中的表达,探讨它们在神经母细胞瘤浸润转移中的可能机制及在治疗中的指导意义.方法应用免疫组化SABC法检测35例神经母细胞瘤中MMP-2、-9及TIMP-2、-1的表达.结果MMP-2在晚期(Ⅲ、Ⅳ期)神经母细胞瘤中的强阳性表达率为79.2%,相对于早期(Ⅰ、Ⅱ、ⅣS期)的18.2%明显升高(P=0.001＜0.01).MMP-9在晚期和早期的强阳性表达率分别为79.2%和36.4%,也具有统计学意义(P=0.017＜0.05).TIMP-2的表达与MMP-2负相关,在早期以强阳性表达为主,在进展期以弱阳性为主(P=0.027＜0.05).结论MMP-2、-9可促进神经母细胞瘤的浸润转移,而TIMP-2对二者有抑制作用.': [0]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029033512', 'counts_by_year': [], 'updated_date': '2024-12-12T16:18:52.023683', 'created_date': '2020-06-05'}