Publication Information

{'id': 'https://openalex.org/W3031872621', 'doi': 'https://doi.org/10.3760/cma.j.issn.0254-5098.2007.06.001', 'title': 'Effect of collagen type IV, MMPs and TIMPs on remodeling of radiation pulmonary injury', 'display_name': 'Effect of collagen type IV, MMPs and TIMPs on remodeling of radiation pulmonary injury', 'publication_year': 2007, 'publication_date': '2007-12-25', 'ids': {'openalex': 'https://openalex.org/W3031872621', 'doi': 'https://doi.org/10.3760/cma.j.issn.0254-5098.2007.06.001', 'mag': '3031872621'}, 'language': 'zh-cn', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN112271200706/157412.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764669166', 'display_name': 'Zhonghua fangshe yixue yu fanghu zazhi', 'issn_l': '0254-5098', 'issn': ['0254-5098'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086600783', 'display_name': '刁瑞英', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': '刁瑞英', 'raw_affiliation_strings': ['100850,北京,军事医学科学院放射与辐射医学研究所'], 'affiliations': [{'raw_affiliation_string': '100850,北京,军事医学科学院放射与辐射医学研究所', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074690902', 'display_name': 'SONG WEN', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': '宋良文', 'raw_affiliation_strings': ['100850,北京,军事医学科学院放射与辐射医学研究所'], 'affiliations': [{'raw_affiliation_string': '100850,北京,军事医学科学院放射与辐射医学研究所', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020348777', 'display_name': '王少霞', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': '王少霞', 'raw_affiliation_strings': ['100850,北京,军事医学科学院放射与辐射医学研究所'], 'affiliations': [{'raw_affiliation_string': '100850,北京,军事医学科学院放射与辐射医学研究所', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081864410', 'display_name': '尹纪业', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': '尹纪业', 'raw_affiliation_strings': ['100850,北京,军事医学科学院放射与辐射医学研究所'], 'affiliations': [{'raw_affiliation_string': '100850,北京,军事医学科学院放射与辐射医学研究所', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 63}, 'biblio': {'volume': '27', 'issue': '06', 'first_page': '517', 'last_page': '520'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T14245', 'display_name': 'Biomarkers in Disease Mechanisms', 'score': 0.9091, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T14245', 'display_name': 'Biomarkers in Disease Mechanisms', 'score': 0.9091, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/radiation-injury', 'display_name': 'Radiation injury', 'score': 0.53665084}, {'id': 'https://openalex.org/keywords/type-i-collagen', 'display_name': 'Type I collagen', 'score': 0.45585096}, {'id': 'https://openalex.org/keywords/pulmonary-injury', 'display_name': 'Pulmonary Injury', 'score': 0.44807577}], 'concepts': [{'id': 'https://openalex.org/C109523444', 'wikidata': 'https://www.wikidata.org/wiki/Q424216', 'display_name': 'Matrix metalloproteinase', 'level': 2, 'score': 0.8426669}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5691339}, {'id': 'https://openalex.org/C2993278735', 'wikidata': 'https://www.wikidata.org/wiki/Q275459', 'display_name': 'Radiation injury', 'level': 3, 'score': 0.53665084}, {'id': 'https://openalex.org/C2780644872', 'wikidata': 'https://www.wikidata.org/wiki/Q14881714', 'display_name': 'Type I collagen', 'level': 2, 'score': 0.45585096}, {'id': 'https://openalex.org/C2910576835', 'wikidata': 'https://www.wikidata.org/wiki/Q1682965', 'display_name': 'Pulmonary Injury', 'level': 4, 'score': 0.44807577}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.3223968}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.30608004}, {'id': 'https://openalex.org/C2781244666', 'wikidata': 'https://www.wikidata.org/wiki/Q32446', 'display_name': 'Pulmonary fibrosis', 'level': 3, 'score': 0.29324162}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2631389}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.17414898}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15301162}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.08675611}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN112271200706/157412.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764669166', 'display_name': 'Zhonghua fangshe yixue yu fanghu zazhi', 'issn_l': '0254-5098', 'issn': ['0254-5098'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.6, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032752798', 'https://openalex.org/W3032694421', 'https://openalex.org/W3032437214', 'https://openalex.org/W3032209312', 'https://openalex.org/W3031505833', 'https://openalex.org/W3031449654', 'https://openalex.org/W3031441417', 'https://openalex.org/W3030868230', 'https://openalex.org/W3030751695', 'https://openalex.org/W3030692868', 'https://openalex.org/W3030333496', 'https://openalex.org/W3030168805', 'https://openalex.org/W3030112887', 'https://openalex.org/W3029779073', 'https://openalex.org/W3029645180', 'https://openalex.org/W3029347836', 'https://openalex.org/W3029118630', 'https://openalex.org/W3029095879', 'https://openalex.org/W3029033512', 'https://openalex.org/W2876226555'], 'abstract_inverted_index': {'目的': [0], '探讨Ⅳ型胶原、基质金属蛋白酶(MMPs)及其组织基质金属蛋白酶抑制剂(TIMPs)在放射性肺损伤早期重建中的作用.方法': [1], '用20Gy60': [2], 'Co': [3], 'γ射线照射大鼠右胸部,建立放射性肺损伤模型,1、2、4周后分别取材;用实时荧光定量PCR和免疫组织化学方法,从基因表达和蛋白质合成水平结合图像分析对肺组织Ⅳ型胶原、MMP-2、MMP-9、TIMP-1和TIMP-2': [4], 'mRNA进行定量分析.结果': [5], '实时定量PCR基因检测:Ⅳ型胶原表达于1周时升高,2周时下降;MMP-2在2周时达高峰,与Ⅳ型胶原成相反变化趋势;MMP-9呈明显的升高、下降、再升高趋势,与Ⅳ型胶原变化趋势相同;TIMP-1表达较低,各时间点之间无明显差异;TIMP-2呈现略升高、降低、升高趋势,与MMP-2表达相反.免疫组化-图像分析:肺组织Ⅳ型胶原含量于1周即明显增加,2周开始下降;MMP-2在2周时下降,随后升高,后期与Ⅳ型胶原呈相反趋势;MMP-9变化趋势同Ⅳ型胶原,但程度明显高于后者;TIMP-1于2周时轻度升高,与MMP-9趋势相反.结论': [6], 'Ⅳ型胶原、MMP-2和MMP-9及其组织抑制物参与放射性肺损伤早期的无效重建过程,MMP-2和MMP-9具有降解Ⅳ型胶原作用;Ⅳ型胶原降解障碍可能与肺纤维化启动有一定关系。': [7]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3031872621', 'counts_by_year': [], 'updated_date': '2024-12-14T15:43:09.854118', 'created_date': '2020-06-05'}