Publication Information

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'https://openalex.org/W3031449654', 'https://openalex.org/W3031441417', 'https://openalex.org/W3031346570', 'https://openalex.org/W3030972956', 'https://openalex.org/W3030868230', 'https://openalex.org/W3030168805', 'https://openalex.org/W3030112887', 'https://openalex.org/W3029779073', 'https://openalex.org/W3029645180', 'https://openalex.org/W3029163938', 'https://openalex.org/W3029118630', 'https://openalex.org/W3029095879', 'https://openalex.org/W3029033512', 'https://openalex.org/W2976592231', 'https://openalex.org/W2603215685'], 'abstract_inverted_index': {'目的': [0], '探讨MMP-2和TIMP-2与胶质瘤侵袭性及恶性表型之间的关系及其意义.方法采用Elivision二步免疫组织化学法染色观察MMP-2和TIMP-2在46例不同恶性度胶质瘤及10例正常脑组织中的表达并用德国LeicaQ550cw图像分析系统测其灰度值作为表达强度的量化指标.结果在对照组、低度及高度恶性胶质瘤中,MMP-2的阳性表达率分别为10%、63.6%和95.8%;在对照组、低度及高度恶性胶质瘤中,TIMP-2的阳性表达率分别为10%、36.3%和37.5%.MMP-2在Ⅰ、Ⅱ级和Ⅲ、Ⅳ级胶质瘤中平均灰度值分别为173.27±13.26和98.63±18.20;TIMP-2在Ⅰ、Ⅱ级和Ⅲ、Ⅳ级胶质瘤中平均灰度值分别为210.44±12.95和205.65±9.75.结论MMP-2表达随胶质瘤恶性程度增加而增强,可作为胶质瘤恶性表型及侵袭性指标之一.TIMP-2表达在正常脑组织及不同级别胶质瘤中无明显差异.MMP-2/TIMP-2的比值与胶质瘤侵袭性密切相关。': [1]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3030442061', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-14T13:43:30.532882', 'created_date': '2020-06-05'}