Title: Expressions of estrogen receptor,progesterone receptor and c-erbB-2 and their relationship with prognosis in breast carcinoma tissues
Abstract:Objective To study expressions of estrogen receptor(ER) ,progesterone receptor(PR) and c-erbB-2 and to ex-plore their relationship with prognosis in breast carcinoma tissues.Methods The immunohistoche...Objective To study expressions of estrogen receptor(ER) ,progesterone receptor(PR) and c-erbB-2 and to ex-plore their relationship with prognosis in breast carcinoma tissues.Methods The immunohistochemical S-P method was used to detect expressions of c-erbB-2,ER and PR from 193 breast carcinoma tissues.Results Expression rate of c-erbB-2,ER and PR was 40.9% ,62.0% and 58.0% ,respectively.Positive expression rate of c-erbB-2 was correlated with tumor histological stage,clinical stage,and axillary lymph node metastasis.The total five-year survival rate was lower in the positive expression of c-erbB-2 group than in the negative group.Expression of ER had positive correlation with PR (P﹤0.01) .The positive expression of c-erbB-2 had negative correlation with ER and PR(P﹤0.05) .Conclusion Detecting expressions of c-erbB-2,ER and PR gene in breast carcinoma tissues has an important role for leading clinical therapy and determining prognosis of breast carcinoma patients.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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