Title: Expression and clinical significance of GST-π,TopoII,estrogen and progesterone receptors in breast carcinoma tissues
Abstract: Objective To examine the expression of Glutathione-s-transferase-π(GST-π),TopoisomeraseⅡ(TopoⅡ),Estrogen receptor(ER),Progesterone receptor(PR) in breast carcinoma tissues and study on clinical relationship between GST-π,TopoⅡ,ER and PR in breast carcinoma.Methods A total of 202 cases with untreated primary breast carcinoma were detected immunohistochemically for GST-π,TopoⅡ,ER and PR.Results The positive expression rate of TopoⅡ was much higher than that of GST-π,ER and PR(P0.05).The positive expression rates of GST-π and TopoⅡ were correlated with invasive mammary carcinoma and clinical stage(P0.05),the positive expression rate of GST-π was correlated with lymph node metastasis and had positive correlation with the expression of ER and PR(P0.05).But there was no relationship between the expression of GST-π and TopoⅡ(P0.05).Conclusion The expression of GST-π,TopoⅡ,ER and PR in breast carcinoma tissues has an instructive significance for leading clinical therapy and for predicting prognosis of patients with breast carcinoma.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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