Title: Pharmacokinetics of Domestic Cilostazol Tablets in Chinese Healthy Volunteers
Abstract:OBJECTIVE To study the pharmacokinetics of cilostazol tablets in humman.METHODS 12male healthy sub jects received a single oral dose of 100mg cilostazol tablets.The plasma concentrations of cilostazol...OBJECTIVE To study the pharmacokinetics of cilostazol tablets in humman.METHODS 12male healthy sub jects received a single oral dose of 100mg cilostazol tablets.The plasma concentrations of cilostazol were determined by an improved HPLC method.Data of plasma level-time were disposed with 3P97 software.RESULTS The main pharmacokinetics parameters of cilostazol were as follow:C_(max) was(937.10±238.10)μg·L~(-1),T_(max)was(3.4±0.8)h,T_(1/2)was(20.4±10.5) h,AUC_(0-72)(12194±4024)μg/(h· L),AUC_(0-∞)was(12689±4325) μg/(h·L).CONCLUSION The pharmacokinetics of cilostazol tablets in human body accorded with wto-compartment open model.The study will offer the parameters of the pharmacokinetics for the clinical application of cilostazol.Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot