Title: Pharmacokinetics of Cilostazol Tablets in Chinese Healthy Volunteers
Abstract:Objective To study the pharmacokinetics of cilostazol tablets in humanbody.Method 12 male healthy subjects received a single oral dose of 100 mg cilostazol tablets.The plasma concentrations of cilosta...Objective To study the pharmacokinetics of cilostazol tablets in humanbody.Method 12 male healthy subjects received a single oral dose of 100 mg cilostazol tablets.The plasma concentrations of cilostazol were determined by an improved HPLC method.Data of plasma level-time were disposed with 3P97 software.Result The main pharmacokinetics parameters of cilostazol were as follow: C_(max) was(769.5±228.2)μg·L~(1),T_(max) was(3.004±1.204)h,T_(1/2)α was(4.72±3.38) h,T_(1/2β) was(25.95±12.22) h,AUC_(0-72) was(12525±3077)μg·h· L~(-1),AUC_(0-∞) was(13003±3206) μg·h·L~(-1).Conclution The pharmacokinetics of cilostazol tablets in human body accorded with two-compartment open model.The study will offer the parameters of the pharmacokinetics for the clinical application of cilostazol.Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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