Title: Pharmacokinetics of Pioglitazone HydrochlorideTablets in Chinese Healthy Volunteers
Abstract:OBJECTIVE: The pharmacokinetics profile of pioglitazone hydrochloride tablets was studied in Chinese healthy volunteers. METHOD: 20 male healthy subjects received a single oral dose of 30mg pioglitazo...OBJECTIVE: The pharmacokinetics profile of pioglitazone hydrochloride tablets was studied in Chinese healthy volunteers. METHOD: 20 male healthy subjects received a single oral dose of 30mg pioglitazone hydrochloride. The plasma concentrations of pioglitazone were determined by an improved HPLC method. RESULTand CONCLUSION: The main pharmacokinetics parameters of pioglitazone were as follows: Cmax was 1172.43 ± 347.01 μg±±·L-1, tmax was 2.16±0.89h, Ke was 0.091±0.023 h-1, t1/2 was 7.75 ± 1.79h, AUC0-tn was 12268.01 ±3542.93 μg·h·L-1, AUC0-∞ 12628.99 ± 3478.25 μg·h·L-1, respectively.Read More
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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