Title: Pharmacokinetics of Picamilon Tablet in Healthy Volunteers
Abstract: OBJECTIVE To study the pharmacokinetics of picamilon tablet in 12 healthy volunteers. METHODS Picamilon tablets were administrated to healthy volunteers,and plasma concentrations were determined by LC-MS. The pharmacokinetic parameters were calculated. RESULTS The oral dose of 50,100 and 200 mg were administrated to volunteers. The pharmacokineitc parameters were as follows:tmax (0.73±0.41),(0.67±0.33) and (0.67±0.31)h,t1/2 (0.68±0.22),(0.89±0.41) and (0.91±0.21)h,ρmax (1 328.75±552.33),(2 460.83±571.19) and (4 415.00±1 077.45) μg·L-1,AUC0-tn (1 617.37±575.48),(3 117.08±620.93) and (5 987.01±1 365.57) μg·h·L-1,AUC0-∞ (1 697.45±584.78),(3 227.39±641.54) and (6 192.36±1 388.59) μg·h·L-1,respectively. The plasma concentration-time curves were described by a two compartment open model. CONCLUSION AUC and ρmax could be increased with the increased dose. No gender effect on pharmacokinetic parameters was found.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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