Title: Pharmacokinetics of domestic cilostazol tablets in Chinese healthy volunteers
Abstract:OBJECTIVE To study the pharmacokinetics of cilostazol tablets in human.METHODS 18 male healthy subjects received a single oral dose of 100 mg cilostazol tablets.The plasma concentrations of cilostazol...OBJECTIVE To study the pharmacokinetics of cilostazol tablets in human.METHODS 18 male healthy subjects received a single oral dose of 100 mg cilostazol tablets.The plasma concentrations of cilostazol were determined by an improved HPLC method.Data of plasma level-time were disposed with 3P97 software.RESULTS The main pharmacokinetics parameters of cilostazol were as follow: C_max was(901.9±221.2)μg·L~-1,t_max was(4.1±1.2)h,t_1/2 was(20.4±9.9) h,AUC_0-72 was(12 722±3 709)μg· L~-1·h,AUC_0-∞ was(13 247±3 847) μg·L~-1·h.CONCLUTION The pharmacokinetics of cilostazol tablets in human body accorded with two-compartment open model.The study can provide pharmacokinetics parameters for the clinical application of cilostazol.Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot