Title: Study on bioequivalence of cilostazol table in healthy volunteers
Abstract:OBJECTIVE To study the bioequivalence of cilostazol tables in healthy volunteers.METHODS 200 mg Test preparation and reference preparation were given to 20 healthy male volunteers in randomized two-wa...OBJECTIVE To study the bioequivalence of cilostazol tables in healthy volunteers.METHODS 200 mg Test preparation and reference preparation were given to 20 healthy male volunteers in randomized two-way crossover design for the pharmacokinetic and relative bioavailability study. Serum concentrations of cilostazol were determined by RP-HPLC.RESULTS The main pharmacokinetic parameters of the two preparation were: tmax(3.350±1.137) and (3.350±1.089) h, Cmax(745.2 ± 208.7) and (732.6±212.9)ng· mL-1, AUC0-t (8777±2158) and (8813±2526)ng·h·mL-1,AUC0-∞(9366±2038)and(9259±2595)ng·h·mL-1, t1/2(Ke)(14.251 ±6.174) and (11.864±3.447)h, Ke(0.059 08 ± 0.028 71) and (0.062 61 ± 0.015 66)h-1,respectively. The mean relative bioavailability of test preparation vs reference preparation were (100.52± 15.52)%.CONCLUSION The statistical analysis shows that the two preparations are bioequivlent.Read More
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot