Title: Pharmacokinetics of 2 Preparations of Cilostazol in Human Body
Abstract:OBJECTIVE:To compare the pharmacokinetics of2preparations of cilostazol in healthy human body.METHODS:22healthy volunteers were administered with single dose of cilostazol100mg either in capsules or t...OBJECTIVE:To compare the pharmacokinetics of2preparations of cilostazol in healthy human body.METHODS:22healthy volunteers were administered with single dose of cilostazol100mg either in capsules or tablets by ranˉdomized crossover way,the blood concentration was determined by HPLC,and the pharmacokinetics parameters and the relaˉtive bioavailability were computed by3p97.RESULTS:The concentration-time curves of cilostazol capsules and cilostazol tablets fitted to two-compartment model.The pharmacokinetics parameters of the capsules vs.the tablets were the following:t max :(3.10±1.09)h vs.(3.43±1.25)h,C max :(0.77±0.27)vs.(0.82±0.42)μg/ml,AUC 0~t :(9.94±2.66)vs.(10.62±3.21)(μg·h)/ml,no significant difference was noted between2preparations from the paired t test(P0.05),the relative bioavailability of the capsules was(95.43±15.47)%.CONCLUSION:2preparations were bioequivalent.Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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