Title: Study on Pharmacokinetics of Compound Telmisartan Tablets in Chinese Healthy Volunteers
Abstract:Objective To conduct study of pharmacokinetics of Telmisartan through taking compound Telmisartan tablets in Chinese healthy volunteers. Methods Twenty healthy volunteers were assigned to a low oral d...Objective To conduct study of pharmacokinetics of Telmisartan through taking compound Telmisartan tablets in Chinese healthy volunteers. Methods Twenty healthy volunteers were assigned to a low oral dose compound tablet or a high oral dose compound tablet. The drug concentrations in plasma were determined by LC-MS/MS method. Results The main pharmacokinetic parameters of Telmisartan were as following: cmax was(111±75)μg/L, tmax was(1.73 ± 1.07)h , AUC0-t was(1 186±877) μg·h·L-1, AUC0-∞ was(1 268±935)μg·h·L-1, t1/2 was(17.6±3.3)h, Vz/F was(52.7±35.7)L/h, CLz/F was(1 268 ± 840)L and MRT was(16.8±3.7)h。 The main pharmacokinetic parameters of Telmisartan were as following:cmax was(651±449)μg/L, tmax was(1.3±0.7)h , AUC0-t was(4 201±3 052)μg·h·L-1, AUC0-∞ was (4 477±3 313)μg·h·L-1, t1/2 was (17.7±4.5)h, CLz/F was (41.6±51.9)L/h, Vz/F was (959±1 231)L and MRT was(15.0±2.7)h。 Conclusion Utilization of LC-MS/MS for determinating the concentration and pharmacokinetics of Telmisartan in human plasma is accurate, sensitive and reliable. The main pharmacokinetic parameters of Telmisartan revealed conform with that reported by domestic and imported articles.Read More
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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