Title: Pharmacokinetics study of mitiglinide tablets in healthy volunteers by HPLC-MS/MS
Abstract:Objective:To study pharmacokinetics of mitiglinide tablets in health volunteers.Methods:A single dose 5 mg and 10 mg mitiglinide tablets was given to 20 healthy volunteers.The pharmacokinetics were me...Objective:To study pharmacokinetics of mitiglinide tablets in health volunteers.Methods:A single dose 5 mg and 10 mg mitiglinide tablets was given to 20 healthy volunteers.The pharmacokinetics were measured.Results:The main pharmacokinetic of 5 mg and 10 mg test tablets were as follow:Cmax were(570.20±76.37) and(899.75±133.67)ng·mL-1;tmax were(0.51±0.13) and(0.51±0.19) h;AUC0-6 were(753.82±355.17) and(1848.68±441.93) ng·h·mL-1;AUC0-∞were(787.74±383.46)and(1957.65±507.04)ng·h·mL-1;t1/2 were(1.91±0.13) and(1.35±0.26) h.Conclusion:The methodology to determine plasma concentration and pharmacokinetic profiles of mitiglinide tablets by HPLC-MS/MS were reachieved.Read More
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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