Title: Effects of smoking on lung mucociliary movement and pulmonary function in patients with chronic obstructive pulmonary disease and healthy people
Abstract:Objective
To observe the effects of smoking on lung mucociliary movement and pulmonary function in patients with chronic obstructive pulmonary disease (COPD) and healthy people.
Methods
Ninety-...Objective
To observe the effects of smoking on lung mucociliary movement and pulmonary function in patients with chronic obstructive pulmonary disease (COPD) and healthy people.
Methods
Ninety-two patients with COPD (COPD group) were selected, including 48 smoking patients (COPD smoking group) and 44 non-smoking patients (COPD non-smoking group). Another 76 healthy people (control group) were selected, including 37 smokers (control smoking group) and 39 non-smokers (control non-smoking group). The saccharin test and pulmonary function were carried out respectively, including mucociliary clearance time (MCT), forced vital capacity (FVC) and forced expired volume in 1 s (FEV1), and the ratio of FEV1 and FVC (FEV1/FVC) and FEV1 percentage of predicted (FEV1%pre) were calculated.
Results
The MCT in COPD group was significantly higher than that in control group: (26.17 ± 19.23) min vs. (15.28 ± 11.34) min, the FEV1/FVC and FEV1%pre were significantly lower than those in control group: (54.25 ± 12.76)% vs. (83.04 ± 5.98)% and (53.26±9.84)% vs. (85.38 ± 5.72)%, and there were statistical differences (P 0.05). The Pearson correlation analysis result showed that there was positive correlation between MCT and smoking intensity, age (r= 0.346 and 0.256, P<0.05), and there was negative correlation between MCT and FEV1/FVC, FEV1%pre (r=-0.327 and-0.414, P<0.05).
Conclusions
Smoking can destroy the mucociliary function and aggravate the deterioration of lung function in patients with COPD.
Key words:
Pulmonary disease, chronic obstructive; Smoking; Respiratory function tests; Saccharin; Mucociliary clearanceRead More
Publication Year: 2017
Publication Date: 2017-07-05
Language: en
Type: article
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