Title: Delta FEV1 and delta FVC : better marker of explanation of COPD
Abstract:Introduction: COPD is a chronic inflammatory airway disease. COPD groups were categorized by symptoms and history of exacerbation. FEV1 is usually considered as marker of actual lung functions. But it...Introduction: COPD is a chronic inflammatory airway disease. COPD groups were categorized by symptoms and history of exacerbation. FEV1 is usually considered as marker of actual lung functions. But it is not correlated well with COPD symptoms. In this article, we evaluated other lung function markers better correlated with COPD symptoms.
Method: We evaluated KOCOSS cohort data. Annual change of FEV1 and FVC were evaluated in 5 year follow up data of spirometry after bronchodilator. Statistical analysis was performed with SPSS. Pearson’s Chi-square test, Student t-test, and one-way ANOVA were proceeded.
Results: Total 957 participants were enrolled in this study. FEV1 and FVC decline were founded in 53.40% and 49.63% each. Baseline characteristics (Ages, sex, smoking status, smoking pack-year, history of exacerbation at entry, bronchiectasis, chronic bronchitis, asthma, emphysema) were not different between groups. In FEV1 based group, exacerbation at fifth year was higher in FEV1 decline group. But functional marker such as 6 minutes walking test, CAT score, SGRQ was not different in FEV1 groups. Compared to FEV1 based group, FVC based groups showed difference in symptom related markers. CAT (14.25±8.27 versus 17.22±9.62, p=0.046) and SGRQ (30.84±17.51 versus 40.14±22.94, p=0.023) were better in higher FVC groups than lower groups.
Conclusion: FEV1 and FVC were correlated marker not independent marker. For better understanding and prediction of COPD, FVC, not just FEV1, should be considered and FVC is a better predictor than FEV1 in some cases.Read More
Publication Year: 2018
Publication Date: 2018-01-01
Language: en
Type: article
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