Publication Information

{'id': 'https://openalex.org/W3028720090', 'doi': 'https://doi.org/10.3760/cma.j.issn.1671-0282.2013.10.011', 'title': 'Activating retinoid X receptor protected rat cardiomyocytes H9c2 from hypoxia/reoxygenation injury', 'display_name': 'Activating retinoid X receptor protected rat cardiomyocytes H9c2 from hypoxia/reoxygenation injury', 'publication_year': 2013, 'publication_date': '2013-10-10', 'ids': {'openalex': 'https://openalex.org/W3028720090', 'doi': 'https://doi.org/10.3760/cma.j.issn.1671-0282.2013.10.011', 'mag': '3028720090'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN11465620132210/441232.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764945285', 'display_name': 'Zhonghua jizhen yixue zazhi', 'issn_l': '1671-0282', 'issn': ['1671-0282'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079283819', 'display_name': 'Peiren Shan', 'orcid': 'https://orcid.org/0000-0002-3004-9759'}, 'institutions': [{'id': 'https://openalex.org/I2801769982', 'display_name': 'First Affiliated Hospital of Wenzhou Medical University', 'ror': 'https://ror.org/03cyvdv85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801769982']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Pei-ren Shan', 'raw_affiliation_strings': ['Department of Cardiology,The First Affiliated Hospitaf of Wenzhou Medical University, Wenzhou 325000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology,The First Affiliated Hospitaf of Wenzhou Medical University, Wenzhou 325000, China', 'institution_ids': ['https://openalex.org/I2801769982', 'https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048660360', 'display_name': 'Zhouqing Huang', 'orcid': 'https://orcid.org/0000-0001-5854-1377'}, 'institutions': [{'id': 'https://openalex.org/I2801769982', 'display_name': 'First Affiliated Hospital of Wenzhou Medical University', 'ror': 'https://ror.org/03cyvdv85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801769982']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhou-qing Huang', 'raw_affiliation_strings': ['Department of Cardiology,The First Affiliated Hospitaf of Wenzhou Medical University, Wenzhou 325000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology,The First Affiliated Hospitaf of Wenzhou Medical University, Wenzhou 325000, China', 'institution_ids': ['https://openalex.org/I2801769982', 'https://openalex.org/I27781120']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007767899', 'display_name': 'Weijian Huang', 'orcid': 'https://orcid.org/0000-0003-2958-134X'}, 'institutions': [{'id': 'https://openalex.org/I2801769982', 'display_name': 'First Affiliated Hospital of Wenzhou Medical University', 'ror': 'https://ror.org/03cyvdv85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801769982']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei-jian Huang', 'raw_affiliation_strings': ['Department of Cardiology,The First Affiliated Hospitaf of Wenzhou Medical University, Wenzhou 325000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology,The First Affiliated Hospitaf of Wenzhou Medical University, Wenzhou 325000, China', 'institution_ids': ['https://openalex.org/I2801769982', 'https://openalex.org/I27781120']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 65}, 'biblio': {'volume': '22', 'issue': '10', 'first_page': '1117', 'last_page': '1122'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9708, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9708, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.9694, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/retinoid-x-receptor', 'display_name': 'Retinoid X receptor', 'score': 0.82536864}, {'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.58277303}, {'id': 'https://openalex.org/keywords/hypoxia', 'display_name': 'Hypoxia', 'score': 0.43454215}], 'concepts': [{'id': 'https://openalex.org/C128821507', 'wikidata': 'https://www.wikidata.org/wiki/Q3454518', 'display_name': 'Retinoid X receptor', 'level': 5, 'score': 0.82536864}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.67775464}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.634498}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.5898707}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.58277303}, {'id': 'https://openalex.org/C2775954498', 'wikidata': 'https://www.wikidata.org/wiki/Q420418', 'display_name': 'Retinoid', 'level': 4, 'score': 0.54389375}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.46668988}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.461591}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.4522692}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4501729}, {'id': 'https://openalex.org/C7836513', 'wikidata': 'https://www.wikidata.org/wiki/Q1641506', 'display_name': 'Hypoxia (environmental)', 'level': 3, 'score': 0.43454215}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4047011}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.39393726}, {'id': 'https://openalex.org/C2781121885', 'wikidata': 'https://www.wikidata.org/wiki/Q425517', 'display_name': 'Retinoic acid', 'level': 3, 'score': 0.38739744}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.29152167}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.27085072}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.26337105}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.25562775}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.24263597}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.209037}, {'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.1657497}, {'id': 'https://openalex.org/C540031477', 'wikidata': 'https://www.wikidata.org/wiki/Q629', 'display_name': 'Oxygen', 'level': 2, 'score': 0.08176905}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.052948385}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN11465620132210/441232.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764945285', 'display_name': 'Zhonghua jizhen yixue zazhi', 'issn_l': '1671-0282', 'issn': ['1671-0282'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.55, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}, {'score': 0.49, 'id': 'https://metadata.un.org/sdg/2', 'display_name': 'Zero hunger'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3138846345', 'https://openalex.org/W3111022034', 'https://openalex.org/W3031066848', 'https://openalex.org/W3030044904', 'https://openalex.org/W3029691087', 'https://openalex.org/W3029007310', 'https://openalex.org/W2990532844', 'https://openalex.org/W2615775332', 'https://openalex.org/W2491740661', 'https://openalex.org/W2416657351', 'https://openalex.org/W2402981017', 'https://openalex.org/W2390805229', 'https://openalex.org/W2384584665', 'https://openalex.org/W2375996613', 'https://openalex.org/W2372462701', 'https://openalex.org/W2364957310', 'https://openalex.org/W2358698904', 'https://openalex.org/W2351396747', 'https://openalex.org/W2086977998', 'https://openalex.org/W2059213901'], 'abstract_inverted_index': {'Objective': [0], 'To': [1], 'determine': [2], 'the': [3, 85, 200], 'protective': [4, 176, 201], 'effects': [5, 177, 202], 'and': [6, 37, 75, 110, 129, 163], 'potential': [7, 102], 'mechanism': [8], 'of': [9, 27, 44, 94, 108, 178, 212], 'activating': [10, 179], 'retinoid': [11], 'X': [12, 219], 'receptor': [13], '(RXR)': [14], 'on': [15, 181], 'rat': [16, 182, 207], 'cardiomyocytes': [17, 43, 58, 95, 183, 208], 'H9c2': [18, 209], 'against': [19, 184, 203], 'hypoxia/reoxygenation': [20], '(H/R)': [21], 'induced': [22, 186], 'oxidative': [23, 187], 'injury.Methods': [24], 'The': [25], 'model': [26], 'H-/R': [28], 'injury': [29, 188, 205], 'was': [30, 49], 'established': [31], 'with': [32, 113, 140, 193], 'hypoxia': [33], 'for': [34, 39], '2': [35], 'hours': [36, 41], 'reoxygenation': [38], '4': [40], 'in': [42, 206], 'H9c2,and': [45], '9-cis-retinoic': [46], 'acid': [47], '(c-RA)': [48], 'obtained': [50], 'as': [51, 55, 120], 'RXR': [52, 56, 141, 180, 194, 198], 'agonist,and': [53], 'HX531': [54], 'antagonist.Cultured': [57], 'were': [59, 118, 132, 189], 'randomly': [60], '(random': [61], 'number)': [62], 'divided': [63], 'into': [64], 'four': [65], 'groups:sham': [66], 'group,H/R': [67, 68], '+': [69, 78], 'c-RA-pretreated': [70], 'group': [71, 80], '(100': [72], 'nmol/L': [73], 'c-RA)': [74], 'H/R': [76, 156, 171, 185, 204], '+c-RA': [77], 'HX531-pretreated': [79], '(2.5': [81], 'μmol/L': [82], 'HX531).We': [83], 'measured': [84], 'cell': [86, 144], 'viability': [87], 'by': [88, 96, 103], 'MTT': [89], '(methyl': [90], 'thiazolyl': [91], 'tetrazolium),apoptosis': [92], 'rate': [93], 'using': [97, 126], 'flow': [98], 'cytometry,and': [99], 'mitochondrial': [100, 148], 'membrane': [101, 149], 'JC-1': [104], 'fluorescent': [105], 'probe,protein': [106], 'levels': [107], 'Bcl-2,Bax': [109], 'cleaved': [111, 164], 'Caspase-9': [112, 165], 'Western': [114], 'blot.All': [115], 'measurement': [116], 'data': [117], 'expressed': [119], '(-x': [121], '±': [122], 's),and': [123], 'statistically': [124], 'analyzed': [125], 'One-way': [127], 'ANOVA': [128], 'Dunnett-t': [130], 'test.Differences': [131], 'considered': [133], 'significant': [134], 'when': [135, 191], 'P': [136], '＜': [137], '0.05.Results': [138], 'Pretreatment': [139], 'agonist': [142], 'enhanced': [143], 'viability,reduced': [145], 'apoptosis': [146, 214], 'ratio,stabilized': [147], 'potential.Dot': [150], 'blotting': [151], 'experiments': [152], 'demonstrated': [153], 'that': [154], 'under': [155], 'stress': [157, 172], 'conditions,Bcl-2': [158], 'protein': [159], 'level': [160], 'decreased,while': [161], 'Bax': [162], 'increased.The': [166], 'c-RA': [167], 'administration': [168], 'prior': [169], 'to': [170], 'prevented': [173], 'these': [174], 'effects,however,overall': [175], 'abolished': [190], 'pretreated': [192], 'pan-antagonist': [195], 'HX531.Conclusions': [196], 'Activating': [197], 'has': [199], 'through': [210], 'attenuation': [211], 'mitochondria': [213], 'signaling': [215], 'pathway.\r\n\r\nKey': [216], 'words:': [217], '\r\nRetinoid': [218], 'receptor;\xa0': [220], 'Cardiomyocytes;\xa0': [221], 'Apoptosis;\xa0': [222], 'Mitochondria;\xa0': [223], 'Hypoxiaq/reoxygenation': [224]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3028720090', 'counts_by_year': [], 'updated_date': '2024-12-15T20:59:44.060601', 'created_date': '2020-06-05'}