Publication Information

{'id': 'https://openalex.org/W2491740661', 'doi': 'https://doi.org/10.3760/cma.j.issn.0253-3758.2016.06.012', 'title': '[Lycopene protects against hypoxia/reoxygenation injury in mouse cardiomyocytes by inhibiting endoplasmic reticulum stress induced apoptosis].', 'display_name': '[Lycopene protects against hypoxia/reoxygenation injury in mouse cardiomyocytes by inhibiting endoplasmic reticulum stress induced apoptosis].', 'publication_year': 2016, 'publication_date': '2016-06-24', 'ids': {'openalex': 'https://openalex.org/W2491740661', 'doi': 'https://doi.org/10.3760/cma.j.issn.0253-3758.2016.06.012', 'mag': '2491740661', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27346266'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27346266', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046932917', 'display_name': 'Jiqian Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I105086349', 'display_name': 'North Sichuan Medical University', 'ror': 'https://ror.org/05k3sdc46', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I105086349']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'J Q Xu', 'raw_affiliation_strings': ['Department of Anesthesiology, North Sichuan Medical College Affiliated Hospital, Nanchong 637000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, North Sichuan Medical College Affiliated Hospital, Nanchong 637000, China', 'institution_ids': ['https://openalex.org/I105086349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045412238', 'display_name': 'Bai-lu Chen', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'B Chen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041111707', 'display_name': 'Houxiang Hu', 'orcid': 'https://orcid.org/0000-0002-6520-2477'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H X Hu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063595483', 'display_name': 'Rongchuan Yue', 'orcid': 'https://orcid.org/0000-0001-6821-1240'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R C Yue', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054989063', 'display_name': 'S Zhang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'S Zhang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111716317', 'display_name': 'Lei Xu', 'orcid': 'https://orcid.org/0000-0002-6226-3063'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'L Xu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003702604', 'display_name': 'H Wang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H Wang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089625532', 'display_name': 'Q Li', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Q Li', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051155963', 'display_name': 'Chunjiang Tan', 'orcid': 'https://orcid.org/0000-0001-8854-1407'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C Y Tan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035988877', 'display_name': 'H Y Chen', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H Y Chen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016718227', 'display_name': 'R Y Zhang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R Y Zhang', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.519506, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 81}, 'biblio': {'volume': '44', 'issue': '6', 'first_page': '518', 'last_page': '23'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase and ATPases Research', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase and ATPases Research', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9521, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/atf6', 'display_name': 'ATF6', 'score': 0.65982807}, {'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.61643714}, {'id': 'https://openalex.org/keywords/hypoxia', 'display_name': 'Hypoxia', 'score': 0.5601716}, {'id': 'https://openalex.org/keywords/cell-sorting', 'display_name': 'Cell Sorting', 'score': 0.421523}], 'concepts': [{'id': 'https://openalex.org/C2779725641', 'wikidata': 'https://www.wikidata.org/wiki/Q1076228', 'display_name': 'CHOP', 'level': 3, 'score': 0.8093809}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.7428116}, {'id': 'https://openalex.org/C2778997996', 'wikidata': 'https://www.wikidata.org/wiki/Q18036598', 'display_name': 'ATF6', 'level': 4, 'score': 0.65982807}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.61643714}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.56123173}, {'id': 'https://openalex.org/C7836513', 'wikidata': 'https://www.wikidata.org/wiki/Q1641506', 'display_name': 'Hypoxia (environmental)', 'level': 3, 'score': 0.5601716}, {'id': 'https://openalex.org/C2780022147', 'wikidata': 'https://www.wikidata.org/wiki/Q208130', 'display_name': 'Lycopene', 'level': 3, 'score': 0.5575597}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.54687357}, {'id': 'https://openalex.org/C16685009', 'wikidata': 'https://www.wikidata.org/wiki/Q335057', 'display_name': 'Andrology', 'level': 1, 'score': 0.50763094}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.47633058}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.43852055}, {'id': 'https://openalex.org/C2778630268', 'wikidata': 'https://www.wikidata.org/wiki/Q17113277', 'display_name': 'Cell sorting', 'level': 3, 'score': 0.421523}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4014174}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39178586}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20918572}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.19063792}, {'id': 'https://openalex.org/C540031477', 'wikidata': 'https://www.wikidata.org/wiki/Q629', 'display_name': 'Oxygen', 'level': 2, 'score': 0.12963066}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.087041736}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002338', 'descriptor_name': 'Carotenoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D059865', 'descriptor_name': 'Endoplasmic Reticulum Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D032383', 'descriptor_name': 'Myocytes, Cardiac', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D051702', 'descriptor_name': 'Activating Transcription Factor 6', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051702', 'descriptor_name': 'Activating Transcription Factor 6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002338', 'descriptor_name': 'Carotenoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015687', 'descriptor_name': 'Cell Hypoxia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000091342', 'descriptor_name': 'Endoplasmic Reticulum Chaperone BiP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015852', 'descriptor_name': 'Eukaryotic Initiation Factor-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015852', 'descriptor_name': 'Eukaryotic Initiation Factor-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077276', 'descriptor_name': 'Lycopene', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D032383', 'descriptor_name': 'Myocytes, Cardiac', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051742', 'descriptor_name': 'Transcription Factor CHOP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051742', 'descriptor_name': 'Transcription Factor CHOP', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000071717', 'descriptor_name': 'X-Box Binding Protein 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000071717', 'descriptor_name': 'X-Box Binding Protein 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051028', 'descriptor_name': 'bcl-2-Associated X Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051028', 'descriptor_name': 'bcl-2-Associated X Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27346266', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3193503532', 'https://openalex.org/W3165149881', 'https://openalex.org/W3124181428', 'https://openalex.org/W3029274913', 'https://openalex.org/W2773873780', 'https://openalex.org/W2605249426', 'https://openalex.org/W2491740661', 'https://openalex.org/W2351166572', 'https://openalex.org/W2351088929', 'https://openalex.org/W2000231571'], 'abstract_inverted_index': {'To': [0], 'investigate': [1], 'the': [2, 51, 95, 136, 148, 165, 172, 204, 212, 221, 233, 243, 255, 275, 280], 'effects': [3], 'of': [4, 68, 78, 108, 139, 157, 215, 228, 237, 247], 'lycopene': [5, 31, 58, 209], 'on': [6], 'primary': [7, 267], 'cultured': [8, 20, 268], 'neonatal': [9, 21, 269], 'mouse': [10, 22, 270], 'cardiomyocytes': [11, 23, 52, 69, 79, 126, 140, 216], 'with': [12, 55, 129, 208], 'hypoxia/reoxgenation': [13], '(H/R)': [14], 'injury': [15], 'and': [16, 99, 110, 155, 168, 174, 226, 240, 242, 250, 278], 'explore': [17], 'related': [18], 'mechanism.Primary': [19], 'were': [24, 53, 112, 194], 'randomly': [25], 'divided': [26], 'to': [27, 93, 133, 203], 'control': [28, 134], 'group': [29, 32, 37, 48, 199], '(control);': [30], '(5': [33], 'μmol/L,': [34], 'lyc);': [35], 'H/R': [36, 47, 63, 198, 205], '(4': [38], 'hours': [39, 44, 61], 'hypoxia': [40], 'followed': [41], 'by': [42, 72, 82, 114], '6': [43], 'reoxgenation);': [45], 'lycopene+': [46], '(lyc+': [49], 'H/R,': [50], 'incubated': [54], '5': [56], 'μmol/L': [57], 'for': [59, 120, 189, 258], '4': [60], 'before': [62], 'treatment).': [64], 'The': [65, 75, 105, 117], 'cell': [66, 137, 213], 'viability': [67, 138, 214], 'was': [70, 80, 91, 127, 141], 'assessed': [71], 'CCK-8': [73], 'assay.': [74], 'apoptotic': [76, 149, 222], 'rate': [77, 150, 223], 'evaluated': [81], 'flow': [83], 'cytometry': [84], 'using': [85], 'AnnexinV-PI': [86], 'double': [87], 'staining.': [88], 'Western': [89], 'blot': [90], 'used': [92], 'determine': [94], 'GRP78,': [96], 'CHOP,': [97], 'Bax': [98], 'Bcl-2': [100], 'protein': [101, 176, 244], 'expression': [102, 177, 235, 245], 'in': [103, 125, 197, 266], 'cardiomyocytes.': [104], 'mRNA': [106, 170, 234], 'expressions': [107], 'ATF6、eIF2α': [109], 'sXbp-1': [111, 169], 'detected': [113], 'real-time': [115], 'PCR.': [116], 'fluorescence': [118, 131, 187, 256], 'intensity': [119, 188, 257], 'reactive': [121], 'oxygen': [122], 'species': [123], '(ROS)': [124], 'measured': [128], 'Olympus': [130], 'microscope.Compared': [132], 'group,': [135, 206], 'significantly': [142, 163, 219, 231, 253], 'reduced': [143, 254], '((64.28±6.12)%': [144], 'vs.': [145, 152, 160, 179, 182, 192], '(100.00±4.98)%,': [146], 'P<0.01),': [147, 218, 230], '((24.42±1.76)%': [151], '(5.16±1.31)%,': [153], 'P<0.01)': [154, 162, 225], 'ratio': [156, 227], 'Bax/Bcl-2': [158], '(2.33±0.20': [159], '1.00±0.09,': [161], 'increased,': [164], 'ATF6,': [166, 238], 'eIF2α': [167, 239], 'expression,': [171], 'CHOP': [173, 248], 'GRP78': [175, 251], '(1.98±0.15': [178], '1.00±0.12,': [180], '2.09±0.11': [181], '1.00±0.09)': [183], 'as': [184, 186], 'well': [185], 'ROS': [190, 259], '((262.13±22.03)%': [191], '(100.00±12.35)%)': [193], 'markedly': [195, 210], 'increased': [196], '(all': [200], 'P<0.01).': [201], 'Compared': [202], 'pretreatment': [207], 'improved': [211], '((81.75±6.85)%,': [217], 'decreased': [220], '((17.24±2.02)%,': [224], 'Bax/Bcl-2(1.64±0.13,': [229], 'down-regulated': [232], 'levels': [236, 246], 'sXbp-1,': [241], '(1.54±0.12)': [249], '(1.53±0.12),': [252], '((171.18±19.09)%,': [260], 'all': [261], 'P<0.01).Lycopene': [262], 'could': [263], 'attenuate': [264], 'hypoxia/reoxygenation-injury': [265], 'cardiomyocytes,': [271], 'possibly': [272], 'through': [273], 'inhibiting': [274], 'ER': [276, 281], 'stress': [277], 'alleviating': [279], 'stress-induced': [282], 'apoptosis.': [283]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2491740661', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}], 'updated_date': '2024-12-20T11:52:24.655092', 'created_date': '2016-08-23'}