Publication Information

{'id': 'https://openalex.org/W2375996613', 'doi': None, 'title': 'Metformin inhibits apoptosis of primary cardiomyocytes', 'display_name': 'Metformin inhibits apoptosis of primary cardiomyocytes', 'publication_year': 2013, 'publication_date': '2013-01-01', 'ids': {'openalex': 'https://openalex.org/W2375996613', 'mag': '2375996613'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTOTAL-LCXB201304023.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764443334', 'display_name': 'Journal of Clinical Cardiology', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4323867245', 'host_organization_name': 'Scientific Archives LLC', 'host_organization_lineage': ['https://openalex.org/P4323867245'], 'host_organization_lineage_names': ['Scientific Archives LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020935517', 'display_name': 'Hai-Mu Yao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210156804', 'display_name': 'First Affiliated Hospital of Zhengzhou University', 'ror': 'https://ror.org/056swr059', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210156804']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yao Haimu', 'raw_affiliation_strings': ['Department of Cardiology,the First Affiliated Hospital,College of Medicine,Zhengzhou University,Zhengzhou,450052,China)'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology,the First Affiliated Hospital,College of Medicine,Zhengzhou University,Zhengzhou,450052,China)', 'institution_ids': ['https://openalex.org/I4210156804']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5020935517'], 'corresponding_institution_ids': ['https://openalex.org/I4210156804'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 65}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.668, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.668, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.6649, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11051', 'display_name': 'Sirtuins and Resveratrol in Medicine', 'score': 0.5975, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/terminal-deoxynucleotidyl-transferase', 'display_name': 'Terminal deoxynucleotidyl transferase', 'score': 0.51122856}], 'concepts': [{'id': 'https://openalex.org/C196795494', 'wikidata': 'https://www.wikidata.org/wiki/Q1624817', 'display_name': 'TUNEL assay', 'level': 3, 'score': 0.9237913}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.90535605}, {'id': 'https://openalex.org/C2780323712', 'wikidata': 'https://www.wikidata.org/wiki/Q19484', 'display_name': 'Metformin', 'level': 3, 'score': 0.85167426}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.62604713}, {'id': 'https://openalex.org/C12519072', 'wikidata': 'https://www.wikidata.org/wiki/Q14914370', 'display_name': 'Caspase 3', 'level': 4, 'score': 0.5393652}, {'id': 'https://openalex.org/C154113507', 'wikidata': 'https://www.wikidata.org/wiki/Q411149', 'display_name': 'Terminal deoxynucleotidyl transferase', 'level': 4, 'score': 0.51122856}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.49651295}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.47093812}, {'id': 'https://openalex.org/C85265743', 'wikidata': 'https://www.wikidata.org/wiki/Q885458', 'display_name': 'Blot', 'level': 3, 'score': 0.44111738}, {'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.4262001}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.36527932}, {'id': 'https://openalex.org/C16685009', 'wikidata': 'https://www.wikidata.org/wiki/Q335057', 'display_name': 'Andrology', 'level': 1, 'score': 0.35609257}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.35009974}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.33139017}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3286803}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.306699}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.25211078}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.24022937}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.11981282}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.116181344}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTOTAL-LCXB201304023.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764443334', 'display_name': 'Journal of Clinical Cardiology', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4323867245', 'host_organization_name': 'Scientific Archives LLC', 'host_organization_lineage': ['https://openalex.org/P4323867245'], 'host_organization_lineage_names': ['Scientific Archives LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3210797226', 'https://openalex.org/W3032247697', 'https://openalex.org/W3030044904', 'https://openalex.org/W2890201889', 'https://openalex.org/W2886893295', 'https://openalex.org/W2463239974', 'https://openalex.org/W2416325980', 'https://openalex.org/W2394120329', 'https://openalex.org/W2390805229', 'https://openalex.org/W2389647314', 'https://openalex.org/W2380841852', 'https://openalex.org/W2380281331', 'https://openalex.org/W2379608844', 'https://openalex.org/W2377214242', 'https://openalex.org/W2364957310', 'https://openalex.org/W2364745446', 'https://openalex.org/W2361756671', 'https://openalex.org/W2358698904', 'https://openalex.org/W2347883465', 'https://openalex.org/W1879367451'], 'abstract_inverted_index': {'Objective:To': [0], 'assess': [1], 'whether': [2], 'there': [3], 'are': [4], 'beneficial': [5], 'effects': [6, 135], 'of': [7, 21, 31, 40, 59, 62, 76, 130, 139, 155], 'metformin': [8, 52], 'action': [9], 'on': [10, 136, 141], 'cardiomyocytes': [11, 25, 92], 'apoptosis': [12, 61, 89, 143], 'damaged': [13], 'due': [14], 'to': [15, 116], 'H2O2.We': [16], 'also': [17], 'illustrated': [18], 'the': [19, 29, 38, 57, 67, 98, 128, 137, 153], 'change': [20], 'Caspase-3': [22, 77, 110], 'level.': [23], 'Method:Primary': [24], 'were': [26, 35, 47, 64], 'cultured': [27], 'from': [28], 'ventricles': [30], 'one-day-old': [32], 'Wistar': [33], 'rats.Cardiomyocytes': [34], 'incubated': [36], 'in': [37, 90, 112, 123], 'presence': [39], '100': [41, 50], 'μmol/L': [42, 51], 'H2O2': [43, 117, 140], 'for': [44, 53, 107], '12': [45], 'h.Cardiomyocytes': [46], 'pretreated': [48], 'with': [49, 121, 151], '60': [54, 108], 'min': [55], 'before': [56], 'addition': [58], 'H2O2.The': [60], 'cells': [63, 113], 'analyzed': [65], 'by': [66, 80], 'terminal': [68], 'deoxynucleotidyl': [69], 'transferase-mediated': [70], 'dUTP': [71], 'nick-end': [72], 'labeling(TUNEL)': [73], 'assay.The': [74], 'expression': [75, 129, 154], 'was': [78, 93, 118], 'evaluated': [79], 'Western': [81], 'blotting.': [82], 'Result:The': [83], 'TUNEL': [84], 'assay': [85], 'showed': [86], 'that': [87, 122], 'cell': [88, 99, 142], 'normal': [91], 'low(5.99±0.61)%.Reactive': [94], 'oxygen': [95], 'species(ROS)': [96], 'increased': [97], 'apoptosis(33.45±1.78)%.Metformin': [100], 'significantly': [101, 126], 'reduced': [102], 'cardiomyocyte': [103], 'apoptosis(7.89±1.12)%': [104], 'after': [105, 114], 'pretreatment': [106], 'min.The': [109], 'level': [111], 'exposure': [115], 'higher': [119], 'compared': [120], 'vehicle-treated': [124], 'cells(P0.05).Metformin': [125], 'inhibited': [127], 'Caspase-3.': [131, 156], 'Conclusion:Metformin': [132], 'has': [133], 'antagonistic': [134], 'influences': [138], 'and': [144], 'attenuate': [145], 'oxidative': [146], 'stress-induced': [147], 'apoptosis,which': [148], 'is': [149], 'associated': [150], 'inhibiting': [152]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2375996613', 'counts_by_year': [], 'updated_date': '2024-12-15T15:27:47.139667', 'created_date': '2016-06-24'}