Title: In-vivo Anti-virus Effect of Baicalein on Influenza A Virus
Abstract:Objective To investigate the anti-virus effect of baicalein on influenza A virus in vivo.Methods NIH mice were randomized into the normal control group,model group,virazole group(at the dose of 0.07g·...Objective To investigate the anti-virus effect of baicalein on influenza A virus in vivo.Methods NIH mice were randomized into the normal control group,model group,virazole group(at the dose of 0.07g·kg-1·d-1),high-,middle-and low-dose baicalein groups(100,10 and 1 μg·kg-1·d-1 respectively).Mice infected models were induced by intranasal drip of influenza A virus strain FM1.The lung index,inhibitory rate of lung index,survival rate and death prevention rate as well as the pathological changes of lungs were observed.Results Compared with the normal control group,the lung index and survival rate were decreased(P0.01),and inflammatory changes were shown in the lungs;the lung index and survival rate were markedly increased in high-dose baicalein group(P0.05 compared with the model group),and the lung inflammatory changes were relieved,the above effects being similar to those of virazole.Conclusion Baicalein exerts certain in-vivo anti-virus effect on influenza A virus.Read More
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 1
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot