Title: Mechanism of Reduning Injection against influenza A/H1N1 virus
Abstract:Objective To investigate the effect of Reduning Injection(RI) on the resistance to influenza A/H1N1 virus and its mechanism. Methods The pneumonic model of BALB/c mice was established by influenza A/H...Objective To investigate the effect of Reduning Injection(RI) on the resistance to influenza A/H1N1 virus and its mechanism. Methods The pneumonic model of BALB/c mice was established by influenza A/H1N1 virus, and the average survival period, survival rate, lung index, viral load, and cytokine level of mice infected by influenza A/H1N1 virus were observed. Results Compared with the model group, RI significantly increased the survival rate and prolonged the average survival period of mice infected by influenza A/H1N1 virus(P 0.05, 0.01). RI significantly reduced the lung index, viral load, contents of IL-6 and TNF-α, while increased the content of IFN-γ(P 0.05, 0.01). Conclusion RI has the certain protective effect on mice infected by influenza A/H1N1 virus. Its mechanism may be related to the improvement of the content of IFN-γ and the decrease of the contents of IL-6 and TNF-α.Read More
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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Cited By Count: 2
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