Title: Influence study of omeprazole on blood drug concentration of risperidone and 9-hydroxy risperidone
Abstract:Objective To observe the influence of omeprazole on blood drug concentration of risperidone and 9-hydroxy risperidone. Methods A total of 20 schizophrenia with gastric ulcer cases were treated by risp...Objective To observe the influence of omeprazole on blood drug concentration of risperidone and 9-hydroxy risperidone. Methods A total of 20 schizophrenia with gastric ulcer cases were treated by risperidone combined with omeprazole for 1 week. Detections of blood drug concentration of risperidone and 9-hydroxy risperidone were made after the omeprazole treatment. Results Before application of omeprazole, blood drug concentration of risperidone and 9-hydroxy risperidone was(29.25±7.82) μg/L. After using omeprazole, blood drug concentration of risperidone and 9-hydroxy risperidone was(37.15±11.68) μg/L. The difference had statistical significance(P0.05). Conclusion Omeprazole can increase the blood drug concentration of risperidone and 9-hydroxy risperidone, which should be monitored in the risperidone combined with omeprazole treatment of schizophrenia with gastric ulcer, and timely adjustment of drug dose is necessary.Read More
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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