Title: PLASMA 9-HYDROXYRISPRRIDONE LEVEL OF RISPERIDONE′S ACTIVE METABOLITE AND ITS CLINICAL SIGNIFICANCE
Abstract:Objective To observe the relationship among oral dose, pla sm a drug level and the clinical significance of risperidone. Methods The study was conducted in 56 patients with schizophrenia. They were di...Objective To observe the relationship among oral dose, pla sm a drug level and the clinical significance of risperidone. Methods The study was conducted in 56 patients with schizophrenia. They were divid ed to receive 3 mg, 4 mg or 5 mg risperidone for 4 weeks. The plasma drug levels of 9-hydroxyrisperidone were measured by HPLC method at the end of Week 4. The PANSS were evaluated at Week 1 and 4. Results The difference of oral dose of risperidone and plasma levels of 9-hydroxyrisperidone were sig nificant between male and female patients. The plasma levels of 9-hydroxyrisper idone were significantly different among the 3 mg, 4 mg and 5 mg group. The oral dose of risperidone was significant positive correlated with the plasma levels of 9-hydroxyrisperidone. The plasma level of 9-hydroxyrisperidone was not corr elation with the decreased rate in PANSS total scores but was significant positi ve correlation with the decreased rate in positive scores. Conclusions The oral dose of risperidone was correlated with the plasma level of 9-hydroxyrisperidone. The oral dose of risperidone and the plasma level of 9- hydroxyrisperidone were lower in female patients than that in male patients so r isperidone can improve the patient′s positive symptoms firstly.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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