Title: Effect of Rifampicin on Blood Concentration of Risperidone
Abstract:Objective To explore the effect of rifampicin on the blood concentration of risperidone so as to provide clinical basis for the reasonable use of risperidone to treat schizophrenics with pulmonany tub...Objective To explore the effect of rifampicin on the blood concentration of risperidone so as to provide clinical basis for the reasonable use of risperidone to treat schizophrenics with pulmonany tuberculosis.Methods 30 schizophrenics with pulmonany tuberculosis were randomly divided into two groups,15 in the study group(risperidone combined with rifampicin) and 15 in the controlled group(risperidone only).After treated with risperidone for at least 2 weeks,rifampicin was combined with risperidone to treat those in the study group,while the controls remained the previous medication.Both groups were treated for 6 weeks.HPLC was used to test the blood concentration of risperidone and 9-hydroxyrisperidone before and at the end of the second and sixth week after the treatment.Results The blood concentration of risperidone and 9-hydroxyrisperidone in the study group reduced significantly,the most of which appeared at the end of two weeks,69.6% and 74.1% respectively.After compared using analysis of covariance(ANCOVA),there were significant differences in the blood concentration of fisperidone and 9-hydroxyrisperidone in the study group at the end of the second and sixth week after the combined treatment.There were also significant differences compared with the controlled group.Conclusion There is an effect of rifampicin on the blood concentration of risperidone to some degree.Much attention should be paid to testingthe blood concentration of risperidone during the combination.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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