Title: The relationship between dose of risperidone and the steady plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients
Abstract:OBJECTIVE To evaluate the relationship between dose of risperidone and the steady plasma concentration of risperidone and 9-hydroxyrisperidone in schizophrenic patients.METHODS The steady plasma conce...OBJECTIVE To evaluate the relationship between dose of risperidone and the steady plasma concentration of risperidone and 9-hydroxyrisperidone in schizophrenic patients.METHODS The steady plasma concentrations of risperidone and 9-hydroxyrisperidone were determined by HPLC-MS method and the relationship between total plasma concentration of risperidone and 9-hydroxyrisperidone and doses are evaluated.RESULTS The steady plasma concentration of RSP had a relationship with administered daily oral dose,r=0.766 8. A much better relationship existed between dialy dose of risperidone and the steady plasma concentration 9-hydroxyrisperidone (r=0.980 0) or the total active moiety,risperidone plus 9-hydroxyrisperidone concentrations(r=0.979 8).CONCLUSION The steady plasma concentrations of 9-hydroxyrisperidone or risperidone plus 9-hydroxyrisperidone were more related to the dialy dose of risperidone than that of risperidone. 9-hydroxyrisperidone has an important role in risperidone clinical application.Read More
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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Cited By Count: 1
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