Title: Plasma drug level of risperidone and its clinical significance
Abstract:Objective:To observe the relationship among oral dose,plasma drug level,and the efficacy and side effects of risperidone.Methods:The controlled study was conducted in 38 patients with schizophrenia.Th...Objective:To observe the relationship among oral dose,plasma drug level,and the efficacy and side effects of risperidone.Methods:The controlled study was conducted in 38 patients with schizophrenia.They were randomly and equally divided to receive 2 or 4 mg risperidone for 8 weeks.The plasma drug level of risperidone and its active metabolite,9-hydroxyrisperidone,were measured by HPLC method at the end of week 2,4 and 8.The PANSS,CGI,TESS,and ESRS were evaluated at week 1,2,4,6 and 8.Results:Risperidone was effective in both positive and negative symptoms of schizophrenia,but the onset of action for positive symptom was quicker than that of the negative.There was a significant difference in plasma drug level of risperidone and its metabolite between 2 mg and 4 mg groups but no significant difference in efficacy.The effective dose range for risperidone and its active metabolite may be 30~45 ng·mL -1.Conclusion:The effective and safe method for medication of risperidone starts with small dose(2~4mg) and then increases in dose gradually.The efficacy and side effect of risperidone can be predicated and prevented by plasma drug concentration of risperidone and its active metabolite.Read More
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 1
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot