Title: Preliminary exploration of serum concentration and reference range of risperidone
Abstract:Objective To establish the reference range of serum concentration by therapeutic drug monitoring of risperidone and 9-hydroxyrisperidone(9-OH-RSP) in a large quantity of patients,and to investigate so...Objective To establish the reference range of serum concentration by therapeutic drug monitoring of risperidone and 9-hydroxyrisperidone(9-OH-RSP) in a large quantity of patients,and to investigate some related factors.Methods A total of 3 670 patients treated by risperidone for at least two weeks were collected.The serum concentration of risperidone and 9-OH-RSP were determined by high-performance liquid chromatography with electrochemical detection.Datas were analyzed by SPSS17.0 software.Results 9-OH-RSP serum concentration(P0.01) and the ratio of 9-OH-RSP/risperidone(P0.01) in female aged 18 to 60 years were signif icantly higher than those in male at the same age;The serum concentration of 9-OH-RSP and risperidone in both female and male aged 18 to 60 years were signifi cantly higher than those in aged over 60 years(female,P0.01;male,P0.05);Multivariate Tests showed that risperidone serum concentration was related to age,gender and drug combination.Conclusion The reference range in serum concentration of risperidone has been set up and the risperidone serum concentration was related to age,gender and combination drug therapy.Read More
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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