Title: Expression and significance of Twist,MMP-2 and MMP-9 in colorectal carcinomas
Abstract: Objective To investigate the expression and significance of Twist,matrix metalloproteinase(MMP)-2 and MMP-9 in colorectal carcinomas.Methods Immunohistochemical SP method was used to examine the levels of Twist protein,MMP-2,MMP-9 in colorectal carcinomas(48 cases) and paracancerous normal tissues(24 cases).Results The positive rates of Twist,MMP-2 and MMP-9 were higher in colorectal carcinoma than those in the tumor-adjacent ormal tissues(47.92%,54.17%,62.5% vs. 12.50%,20.83%,25.00%)(P0.05).Their expressions were positively correlated with the tumor differentiation,the depth of invasion lymph node metastasis(P0.05).Expression of Twist was positively correlated with that of MMP-2 and MMP-9(P0.01).Expression of MMP-2 was positively correlated with that of MMP-9(P0.01).Conclusion The aberrant expressions of Twist,MMP-2 and MMP-9 may play a cooperative role in the infiltration and metastasis of colorectal carcinomas,which may be taken as a reference index for evaluating the metastasis and prognosis.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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