Title: Clinical Significance of FAT10 Expression Level in Colorectal Carcinomas
Abstract: Objective To study the expression of FAT10 in colorectal cancer tissue.And analysed the relationship between the expression of FAT10 and the character of clinical pathology in colorectal carcinomas.Methods FAT10 mRNA expression in 51cases of colorectal carcinoma,paracancerous tissue and their normal colorectal tissue were detected by using reverse transcription-polymerase chain reaction(RT-PCR).The relation between FAT10 mRNA expression and the character of clinical pathology were observed.Results(1)By RT-PCR method,the positive expression rates of FAT10 in colorectal carcinomas were 68.6%,the positive expression rates of FAT10 in paracancerous tissue and normal colorectal tissu were 17.6% and 13.7%.(2)The levels of FAT10 in tissue of colorectal carcinomaswere obviously higher than that of paracancerous tissue group and normal colorectal group(P0.05).Compared with the group of no lymph node metastasis,the FAT10 levels of lymph node metastasis group was obviously higher(P0.05).The intensity of FAT10 expression in tissue of colorectal carcinomas was correlated with liver metastasis(P0.05).The FAT10 levels were positively related with clinical stages.And the levels of FAT10 had ascending trends according to the clinical stages.The FAT10 levels were no correlated with age,sex,the position of tumor occurrence diameter of tumor,the extent of polarization and other clinicpathological factors.Conclusion Expression of FAT10 was highly upregulated in colorectal cancer,but not in the paracancerous tissue group and normal colorectal group.The abnormal expression of FAT10 may play important roles in the tumorigenesis and progression of colorectal carcinoma.Expression of FAT10 had the association with lymph nodes metastasis,liver metastasis and the clinic type of pathology.It may have the important significance on forecasting the invasion and metastasis of colon carcinomas.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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