Title: The Relationship between the Expression of MMP-2 and p53 and Tumor′s Invasion and Metastasis in Colorectal Carcinoma
Abstract: Objective To investigate the expression of matrix metalloproteinase-2(MMP-2) and p53 in colorectal carcinoma and its relationship with clinical pathological features.Methods Expressions of MMP-2 and p53 were detected by EliVisionTM plus immunohistochemical method in tissues from 40 patients with colorectal carcinoma,20 cases with adenoma and 20 normal intestine tissues.Results The positive rates of MMP-2 and p53 in the tissues from 40 cases of colorectal carcinoma were 80.0%(32/40)and 82.5%(33/40),respectively,which were significantly higher than those in adenoma(0、30.0%) and normal intestine(0、30.0%).The expression of MMP-2 and p53 was not correlated with the age,gender,tumor size and the location of tumor(P0.05),whereas pathological grade,lymph node metastasis and TNM stage were significantly correlated with the MMP-2 and p53 expression(P0.05).MMP-2 expression was correlated with infiltration depth and distant metastasis(P0.05).The expression of p53 was not correlated with the infiltration depth and distant metastasis(P0.05).There was a positive correlation between the expression of MMP-2 and that of p53(rs′=0.3742,P=0.0069).Conclusion The expression of MMP-2 is correlated with lymph node invasion in colorectal carcinomas.p53 gene mutation could up-regulate the MMP-2 expression.Combined detection of the MMP-2 and p53 expression might be helpful in the evaluation of the prognostic factors in patients with colorectal carcinoma.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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Cited By Count: 3
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