Title: Expression of Twist,E-cadherin and β-catenin in colorectal carcinoma
Abstract: Objective To investigate the expression of Twist,E-cadherin and β-catenin in colorectal carcinoma tissue and its association with pathological features.Methods The expression of Twist,E-cadherin and β-catenin in 60 cases of colorectal carcinoma and 20 cases of paracancerous normal tissues was detected by using immunohistochemistry.Results The positive rate of Twist in colorectal carcinoma(53.3%) was significantly higher than that in paracancerous normal tissue(0%).The positive rate of E-cadherin in colorectal carcinoma(35.0%) was significantly lower than that in paracancerous normal tissue(100%).The positive rate of β-catenin in colorectal carcinoma(18.3%) was significantly lower than that in paracancerous normal tissue(100%).The aberrant expression of Twist,E-cadherin and β-catenin was significantly correlated with tumor differentiation,depth of invasion,lymph node metastasis,TNM staging(P0.05),but not correlated with age,gender and size of the tumor(P0.05).Expression of Twist in colorectal carcinomas tissue was negatively correlated with E-cadherin and β-catenin(P0.01).Conclusions Expression of Twist,E-cadherin and β-catenin might play a cooperative role in the onset of malignant progression of colorectal carcinomas.Twist might be a new prognostic marker of malignancy and a potential therapeutic target in colorectal cancer.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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