Title: Effect and sarety combination therapy of magnesium valproate with quetiapine on recurrent mania
Abstract: Objective The study was to explore the effectiveness and safety of chronic combination treatment of magnesium valproate with quetiapine on recurent mania.Method All 66 affective disorder patients with mania-onset were randomly assigned to receive magnesium valproate(n=33),and magnesium valproate with quetiapine(n=33),In acute phase treatment of 6 weeks after 5 years.At baseline,the symptom was evaluated with the Bech-Rafaelsen Manin Rating Scale(BRMS).The drug dosage,times of relapse,effectsand safety was compared among the three groups.Results After the acute therapy,the reductions in BRMS score were(42±27)% in magnesium valproate group,(57±24)% in combination group,respectively,with significant differences between the two groups(P0.05).At followed-up 5 years,mania relapse times was significantly less in combination group than that in magnesium valproate group(mean times of 1.9±1.6,3.3±2.0,P0.01);depression relapse times was no differences in both groups(mean times of 1.8±2.0,1.9±1.8,P0.05).The mean dosage of single drug in combination groups was significantly lower than that in magnesium valproate(P0.01).There were no significantly statistic differences on side-effects two groups.Conclusion It is suggested that the efficacy of combination therapy of magnesium valproate with quetiapine on mania be better than monotherapy with magnesium valproate with the same safety.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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