Title: The control study of Quetiapine and Risperidone combined with magnesium valproate sustained release tablets in treatment of mania
Abstract: Objective:To compare the effects and safety of Quetiapine and Risperidone combined with magnesium valproate sustained release tablets in the treatment of mania.Methods:65 cases of mania patients were randomly divided into the study group and the control group.Both groups of patients had taken magnesium valproate sustained release tablets for 6 weeks,the study group patients were given Quetiapine,and the control group were received Risperidone.the effects were assessed with the BRMS and adverse effects with the TESS before treatment,at the end of the 1st,2nd,4th and 6th week treatment.Results: there were no significant differences between the study group and the control group in the effects at the end of the 6th week,but at the end of the 1st week,the BRMS scores of the study group declined much quicker(P0.05),EPS and endocrine changes were lower than the control group(P0.05).Conclusions: the effects of two groups are significant and equivalent,however,the study group takes effect faster,less adverse effects and better safety.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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