Title: Comparison of clinical effects and adverse reactions of sodium valproate and quinolapine combined with lithium carbonate for patients with episodes bipolar disorder
Abstract: Objective
To compare the treatment effects and adverse reactions of sodium valproate and quinolapine combined with lithium carbonate for patients with episodes bipolar disorder.
Methods
Sixty-eight patients with episodes bipolar disorder were included in this study, and they were divided into two groups according to the random method, with 34 cases in each group. The group A was treated with quetiapine and lithium carbonate, while the group B was treated with sodium valproate and lithium carbonate. Then, the differences of clinical effects and safety of the two groups after the treatment for 4 weeks were evaluated.
Results
There was no significant difference in BRMS or PANSS scores, the total treatment efficiency, the incidence of adverse reactions or the frequency of manic episodes, the number of hospitalization or the hospitalization time after the treatment for 4 weeks between the group A and group B (P>0.05). But after 1 week of treatment, the score of BRMS and PANSS in group A was significantly lower than that in group B (P<0.05).
Conclusions
On the basis of lithium carbonate, the clinical effect and safety of sodium valproate combined with quetiapine in the treatment of episodes bipolar disorder are good, and the quetiapine are faster and more beneficial to the early recovery of the patients.
Key words:
Episodes bipolar disorder; Sodium valproate; Quinolapine; Lithiumcarbonate; Clinical effect
Publication Year: 2018
Publication Date: 2018-05-25
Language: en
Type: article
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