Title: THE RATE OF CLINICAL RESPONSE OF ORAL LOADING SODIUM VALPROATE IN ACUTELY MANLC PATIENT
Abstract: Introduction: Acheiving accelerated clinical response is desirable in patients with acute manic episode. We conducted a prospective study to compare the rate of clinical response of oral loading sodium valproate versus standard dose titration.
Methods: Fourty - two patients who met DSM - IV critevia for current manic episode and who had a Young mania rating scale score between 20 and 50 were randomly assigned on a double blind basis to recieve valproate oral loading(N = 21) at a dose of 20 mg/kg in divided doses for 7 days and valproate non -loading at a starting dose of 10 mg/kg followed by standard titration which at day 6 , they recieved 20 mg/kg valproate. Patients were scored at day 0, 3, 5 and 7 by a blindraterusing YMRS.
Results: There was no significat differences between the groups in advers events and useing of adjunctive tranquilizer .The efficacy of valproate in both two groups was similar but the rate of improvement on YMRS over the first 3 days was significantly greater in loading group.
Conclusion: Valproate oral loading with sodium valproate can induced a more rapid clinical response in acutely manic patient.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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Cited By Count: 1
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