Title: Study on expressions of Livin and Smac proteins in non-small cell lung cancer and their clinical significance
Abstract: OBJECTIVE: To investigate the expressive characteristics of Livin and Smac proteins in non-small cell lung cancer(NSCLC),and analyze their affections to NSCLC patients' prognosis.METHODS: The expressions of Livin and Smac proteins were detected in 89 NSCLC tissue samples and 25 normal lung tissue samples by immunohistochemical technique.RESULTS: The positive expression rates of Livin and Smac proteins stained in NSCLC tissues were 53.9%(48/89) and 58.4%(52/89) respectively,which were higher than those in normal lung tissues,and χ2 were 16.723 and 16.848,P was 0.000.Livin protein expression was correlated with Smac protein significantly,χ2=18.451,P=0.000,r=0.455.Among all tumors,the expressive level of Livin protein was closely related to the lymph node metastasis(χ2=19.433,P=0.000),TNM stages(χ2=17.161,P=0.000)and histological types(χ2=7.772,P=0.021),but not to sex,age and differentiation grades,P0.05.The expressive level of Smac protein was closely related to the lymph node metastasis(χ2=7.748,P=0.005),TNM stages(χ2=7.064,P=0.008),but not to sex,age and histological types,P0.05.Kaplan-Meier analysis revealed a significant impact on survival by Livin protein in NSCLC,χ2=7.407,P=0.006,but not by Smac protein,χ2=0.945,P=0.331.CONCLUSIONS: Overexpression of Livin protein is closely related to the occurrence and progression of NSCLC.Moreover,it might bring side effect to the prognosis.Although the overexpression of Smac protein affects the occurrence and progression of NSCLC,it has no relationship with the prognosis.Livin protein may be helpful to evaluate the progression of NSCLC,and to predict the prognosis.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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