Title: The expression of FAF1 and Livin proteins in gastric carcinoma and its clinical significance
Abstract: Objective To explore the expression of FAF1 protein and Livin protein in gastric cancer tissues and its significance. Methods The expression of FAF1 protein and Livin protein was detected in 53 cases of gastric cancer and 50 normal subjects using immunohistochemical methods,respectively. Results ①The positive rate of FAF1 expression in the gastric cancer tissues was lower than that in the normal tissues( 28. 30% vs 84. 00%,χ2= 32. 30,P 0. 05). ②The positive rate of Livin expression in the gastric cancer tissues was higher than that in the normal tissues( 73. 58 vs 14%,χ2= 36. 96,P 0. 05). ③The expression of FAF1 was significantly related with the histological differentiation( P 0. 05),while the expression of Livin was significantly correlated to the tumor diameter,infiltration degree,differentiation degree,lymph node metastasis and TNM staging( P 0. 05). ④There was no correlation between the expression of FAF1 and Livin( rs= 0. 307,P 0. 05). Conclusion Lack of FAF1 expression may play an important role in the occurrence and development of gastric cancer and inhibit the cancer cell differentiation. The Livin protein abnormal expression may be associated with the occurrence,development,invasion and metastasis of gastric cancer. The combined detection of FAF1 and Livin proteins provides an important basis for early diagnosis and inference of the evolution of gastric cancer.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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Cited By Count: 1
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