Title: Correlation Analysis between Expressions of p53, bcl-2 and caspase-3 in Patients with Non-Small Cell Lung Cancer
Abstract: Objective To investigate the expressions of p53,bcl-2 and caspase-3 in elderly patients with advanced non-small cell lung cancer(NSCLC),and the clinical significance thereof.Methods The clinical data and paraffin tissue samples of 117 patients with NSCLC confirmed by postoperative pathology were collected.The expressions of p53,bcl-2 and caspase-3 protein in tissues of NSCLC were detected by immunohistochemical method.The correlation between the expressions of p53,bcl-2 and caspase-3 protein was analyzed,and the relationship between the expressions of p53,bcl-2 and caspase-3 protein and clinicopathological characteristics was explored.Results The positive expression rates of p53,bcl-2and caspase-3 were 42.74%(50/117),38.46%(45/117) and 36.75%(43/117) in tissue samples of NSCLC.The positive expression rate of p53 was significantly higher in patients with poor differentiation,central type,lymph node metastasis and squamous carcinoma.The positive expression rate of bcl-2 was significantly higher in patients with high differentiation and lymph node metastasis.The positive expression rate of caspase-3 was significantly higher in patients with high differentiation and no lymph node metastasis.There was a positive correlation between expressions of bcl-2 and caspase-3 in NSCLC(r=0.262,P=0.003).Conclusion The expressions of p53,bcl-2 and caspase-3 may play important roles in development and progression of advanced NSCLC in elderly patients,which may serve as predicators for prognosis.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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