Title: The relationship between vascular endothelial growth factor C expression and lymphangiogenesis as well as prognosis in human laryngeal carcinoma
Abstract: Objective To investigate the expression of vascular endothelial growth factor-D in patients with laryngeal cancer,and the relationship with lymphangiogenesis lymph node metastasis and their prognosis significance.Methods Forty five specimens of the laryngeal cancer and twenty benign laryngeal diseases were studied.The expression of VEGF-D was observed by immunohistochemistry staining S-P method.LVD was evaluated by 5′-Nucleotides-alkaline phosphates double staining,then judged the role of VEGF-D in laryngeal cancer prognosis by using Kaplan-Meier method.Results ①During 45 laryngeal cancer samples,the positive rate of VEGF-D was 37.8%,the expression was much higher in tumor tissue than in the normal tissue(P0.05).②The expression of VEGF-D was significantly correlated with peritumoral LVD,intratumoral LVD,lymph nodes metastasis,lymphovascular invasion(P0.01).But there was no significant association with their age,gender,histological stage,location and TNM stage(P0.05).③Kaplan-meier test indicated the different expression of VEGF-D had effect on survival ratio(P0.05).Conclusion The expression of VEGF-D protein is correlate with lymphangiogenesis and lymphatic metastasis.VEGF-D protein may be helpful for judging prognosis in laryngeal cancer.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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