Title: The Correlation of Endothelin 1 and Lymphangiogenesis,Angiogenesis in Laryngeal Carcinoma
Abstract: Objective To investigate the expression of endothelin1(ET-1) in patients with laryngealcarcinoma and the relationship with lymphangiogenesis,angiogenesis and their prognosis significance.Meth-ods The expression of ET-1 protein was observed by immunohistochemistry staining and western blot in 45laryngeal carcinoma samples and 10 normal tissues samples.LVD was evaluated by 5'-Nucleotides staining,MVD was evaluated by immunohistochemistry with the antibody CD34.The correlation analysis was made be-tween ET-1 and clinical parametersa,nd judged the role of ET-1 in laryngeal cancer prognosis by using Kap-lan-Meier method.Results The level of ET-1 protein was much higher in tumor tissue than that in the nor-mal tissue(P 0.05).The expression of ET-1 protein was significantly correlated with LVD,MVD,TNMstagel,ymph nodes metastasis and lymphovascular invasion(P 0.05).Kaplan-Meier method indicatedthere was no significantly association between the positive expression of ET-1 and survival ratio(P 0.05).Conclusion The expression of ET-1 protein was correlated with lymphangiogenesis and angiogenesis,but there was no significantly association between ET-1 and prognosis in laryngeal carcinoma.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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