Title: The relationship between vascular endothelial growth factor D expression and lymphangiogenesis as well as prognosis in human laryngeal carcinoma
Abstract: Objective To investigate the expression of vascular endothelial growth factor D(VEGF-D) in human laryngeal cancer to explore the relationship of the expression with lymphangiogenesis,lymph node metastasis and their prognosis significance. Methods Forty five specimens of human laryngeal cancer and twenty benign laryngeal tissues were used to observe the expression of VEGF-D by immunohistochemistry S-P method. The lymphatic vessels density(LVD) was evaluated by 5'-Nucleotides-alkaline phosphates double staining,then the role of VEGF-D in laryngeal cancer prognosis was judged by Kaplan-meier method. Results The positive rate of VEGF-D expression is 42.2% in 45 laryngeal cancer samples,which is much higher in tumor tissue than in the normal tissue( 0.05) . The expression of VEGF-D was significantly correlated with peritumoral LVD,intratumoral LVD,lymph nodes metastasis and lymphovascular invasion( 0.01) ,but with no significant association with their age,gender,histological stage,location and TNM stage( 0.05) . Kaplan-meier test indicated that the expression of VEGF-D was positively correlated with survival rate( 0.05) . Conclusion The expression of VEGF-D protein was correlated with lymphangiogenesis and lymphatic metastasis,which may be helpful for judging prognosis in laryngeal cancer treatment.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot