Publication Information

{'id': 'https://openalex.org/W2347298436', 'doi': None, 'title': 'Research on the Mechanism of Dioscin-Containing Serum Against Apoptosis of Cardiomyocytes Induced by Hydrogen Peroxide', 'display_name': 'Research on the Mechanism of Dioscin-Containing Serum Against Apoptosis of Cardiomyocytes Induced by Hydrogen Peroxide', 'publication_year': 2012, 'publication_date': '2012-01-01', 'ids': {'openalex': 'https://openalex.org/W2347298436', 'mag': '2347298436'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGYX201219008.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764966987', 'display_name': 'Zhōnghuá yàoxué zázhì', 'issn_l': '1016-1015', 'issn': ['1016-1015'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4323237738', 'host_organization_name': 'Pharmaceutical Society of the Republic of China', 'host_organization_lineage': ['https://openalex.org/P4323237738'], 'host_organization_lineage_names': ['Pharmaceutical Society of the Republic of China'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100430796', 'display_name': 'Xi Zhang', 'orcid': 'https://orcid.org/0000-0001-5777-2368'}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Zhang Xi', 'raw_affiliation_strings': ['2,WANG Yun 2,LI Xin2,KANG Yi2,SONG Jun-qiu2'], 'affiliations': [{'raw_affiliation_string': '2,WANG Yun 2,LI Xin2,KANG Yi2,SONG Jun-qiu2', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5100430796'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 64}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12215', 'display_name': 'Phytochemical Studies and Bioactivities', 'score': 0.5977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12215', 'display_name': 'Phytochemical Studies and Bioactivities', 'score': 0.5977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11709', 'display_name': 'Traditional Chinese Medicine Analysis', 'score': 0.5408, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.6254095}, {'id': 'https://openalex.org/keywords/fragmentation', 'display_name': 'Fragmentation', 'score': 0.5700097}, {'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.4733175}, {'id': 'https://openalex.org/keywords/crude-drug', 'display_name': 'Crude drug', 'score': 0.43968296}], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.8023014}, {'id': 'https://openalex.org/C533411734', 'wikidata': 'https://www.wikidata.org/wiki/Q171877', 'display_name': 'Hydrogen peroxide', 'level': 2, 'score': 0.7648525}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.68126595}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6411328}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.6254095}, {'id': 'https://openalex.org/C191015642', 'wikidata': 'https://www.wikidata.org/wiki/Q1132459', 'display_name': 'Fragmentation (computing)', 'level': 2, 'score': 0.5700097}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.49888563}, {'id': 'https://openalex.org/C43759708', 'wikidata': 'https://www.wikidata.org/wiki/Q3749256', 'display_name': 'DNA fragmentation', 'level': 4, 'score': 0.48481622}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.4733175}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.45934138}, {'id': 'https://openalex.org/C2778956427', 'wikidata': 'https://www.wikidata.org/wiki/Q735160', 'display_name': 'Crude drug', 'level': 2, 'score': 0.43968296}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4372642}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.28871578}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.26285273}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.21283922}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.09351596}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGYX201219008.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764966987', 'display_name': 'Zhōnghuá yàoxué zázhì', 'issn_l': '1016-1015', 'issn': ['1016-1015'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4323237738', 'host_organization_name': 'Pharmaceutical Society of the Republic of China', 'host_organization_lineage': ['https://openalex.org/P4323237738'], 'host_organization_lineage_names': ['Pharmaceutical Society of the Republic of China'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.59, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032247697', 'https://openalex.org/W2416325980', 'https://openalex.org/W2394400483', 'https://openalex.org/W2393034008', 'https://openalex.org/W2390805229', 'https://openalex.org/W2390177627', 'https://openalex.org/W2389647314', 'https://openalex.org/W2380281331', 'https://openalex.org/W2376974606', 'https://openalex.org/W2375996613', 'https://openalex.org/W2371003965', 'https://openalex.org/W2368065582', 'https://openalex.org/W2365860217', 'https://openalex.org/W2364957310', 'https://openalex.org/W2364203628', 'https://openalex.org/W2361150159', 'https://openalex.org/W2359871133', 'https://openalex.org/W2358289206', 'https://openalex.org/W2347883465', 'https://openalex.org/W2183175054'], 'abstract_inverted_index': {'OBJECTIVE': [0], 'To': [1], 'discuss': [2], 'the': [3, 52, 76, 90, 108, 128, 135, 162, 171, 176, 182, 185, 197, 209], 'mechanism': [4], 'of': [5, 9, 66, 84, 92, 96, 122, 134, 158, 165, 184, 199], 'dioscin': [6, 85], 'against': [7], 'apoptosis': [8], 'cardiomyocytes': [10, 44, 67, 136, 188], 'induced': [11, 192], 'by': [12, 27, 47, 62, 70, 88, 102], 'hydrogen': [13, 48, 190], 'peroxide': [14, 49, 191], 'through': [15], 'Serum': [16], 'Pharmacologic': [17], 'Method.METHODS': [18], 'The': [19, 111], 'drug-containing': [20, 53, 77, 109, 123, 130, 155], 'serum': [21, 28, 54, 78], '[0.6': [22], 'g(crude': [23, 125], 'drug)·kg-1]': [24], 'was': [25, 60, 86, 114], 'prepared': [26], 'pharmacologic': [29], 'method.Cardiomyocytes': [30], 'from': [31, 127], 'neonatal': [32], 'SD': [33], 'rats': [34], 'were': [35, 45, 68, 100, 148], 'cultured': [36, 43, 187], 'in': [37, 189], 'Dulbecco': [38], 'Modified': [39], 'Eagle': [40], 'Medium(DMEM).The': [41], 'primary': [42, 186], 'injured': [46], 'before': [50], 'giving': [51], 'with': [55, 75, 107, 119, 154, 161], 'different': [56, 80, 120], 'concentrations.The': [57, 81], 'cardiomyocyte': [58, 112], 'viability': [59, 113, 183], 'determined': [61], 'MTT': [63], 'method.Morphological': [64], 'changes': [65], 'observed': [69], 'fluorescence': [71], 'microscope': [72], 'after': [73, 105, 116, 151], 'treating': [74, 106], 'at': [79], 'anti-apoptotic': [82], 'effect': [83], 'indicated': [87], 'detecting': [89], 'activity': [91, 157, 198], 'caspase-3.The': [93], 'protein': [94], 'expression': [95], 'Bcl-2': [97, 172, 205], 'and': [98, 142, 146, 203, 207], 'Bax': [99, 177, 210], 'semi-quantified': [101], 'Western-blot': [103], 'method': [104], 'serum.RESULTS': [110], 'elevated(P0.01)': [115], 'being': [117, 152], 'treated': [118, 153], 'concentrates': [121], 'serum(0.4,0.8,1.2': [124], 'drug)·kg-1,prepared': [126], 'original': [129], 'serum).Typical': [131], 'apoptotic': [132], 'features': [133], 'such': [137], 'as': [138], 'membrane': [139], 'blebbing,cell': [140], 'shrinkage': [141], 'detachment,and': [143], 'nucleus': [144, 201], 'condensation': [145, 202], 'fragmentation': [147], 'dose-dependently': [149], 'improved': [150], 'serum.The': [156], 'caspase-3': [159], 'decreased': [160], 'increasing': [163], 'concentration': [164], 'drug.Western': [166], 'blot': [167], 'approach': [168], 'showed': [169], 'that': [170], 'level': [173, 206], 'increased': [174], 'meanwhile': [175], 'decreased.CONCLUSION': [178], 'Dioscin': [179], 'could': [180, 194], 'increase': [181], 'injury.It': [193], 'also': [195], 'decrease': [196, 208], 'caspase-3,improve': [200], 'fragmentation,increase': [204], 'level.': [211]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2347298436', 'counts_by_year': [], 'updated_date': '2024-12-10T17:38:23.913549', 'created_date': '2016-06-24'}