Publication Information

{'id': 'https://openalex.org/W3031869021', 'doi': 'https://doi.org/10.3760/cma.j.issn.1001-2346.2015.11.020', 'title': 'Effect of miR-15b on proliferation and apoptosis of human glioma cell line A172', 'display_name': 'Effect of miR-15b on proliferation and apoptosis of human glioma cell line A172', 'publication_year': 2015, 'publication_date': '2015-11-28', 'ids': {'openalex': 'https://openalex.org/W3031869021', 'doi': 'https://doi.org/10.3760/cma.j.issn.1001-2346.2015.11.020', 'mag': '3031869021'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.3760/cma.j.issn.1001-2346.2015.11.020', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 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'https://openalex.org/W3030539979', 'https://openalex.org/W3030500488', 'https://openalex.org/W3030275518', 'https://openalex.org/W3029950332', 'https://openalex.org/W3029735080', 'https://openalex.org/W3028807183', 'https://openalex.org/W3024753914', 'https://openalex.org/W2579931245', 'https://openalex.org/W2401202617', 'https://openalex.org/W2114402182', 'https://openalex.org/W2073535909', 'https://openalex.org/W155884375'], 'abstract_inverted_index': {'Objectives\r\nTo': [0], 'observe': [1], 'the': [2, 30, 45, 62, 83, 87, 91, 95, 108, 114, 128, 166, 179, 188, 193, 203, 235, 240, 244, 249, 265, 273, 278, 285, 310], 'effect': [3, 63], 'of': [4, 10, 47, 64, 111, 131, 143, 151, 178, 207, 226, 239, 264, 287, 296, 312], 'miR-15b': [5, 27, 48, 65, 74, 96, 112, 124, 172, 180, 208, 214, 250, 266, 297], 'on': [6, 49, 66], 'proliferation': [7, 52, 286], 'and': [8, 16, 38, 53, 68, 99, 104, 135, 156, 162, 192, 248, 256, 277, 290], 'apoptosis': [9, 237, 262], 'human': [11], 'glioma': [12, 288], 'cell': [13, 32, 51, 175, 198, 204, 218, 236, 261], 'line': [14], 'A172': [15, 31, 50, 115, 167, 217, 260], 'to': [17, 43, 60, 81, 304], 'investigate': [18], 'its': [19, 69], 'role': [20], 'in': [21, 86, 113], 'RAS/MEK/ERK1/2': [22, 299], 'signaling': [23, 71, 300], 'pathway': [24, 301], 'cells.\r\n\r\n\r\nMethods\r\nThe': [25], 'synthetic': [26], 'mimics': [28, 97, 125, 181, 209, 215, 251, 267], 'transfected': [29, 170], 'line.': [33], 'Methylthiazol': [34], 'tetrazoliu': [35], '(MTT)': [36], 'assay': [37, 57, 145], 'flow': [39], 'cytometry': [40], 'were': [41, 101, 153, 253], 'used': [42, 59], 'assess': [44], 'effects': [46], 'apoptosis.': [54, 292], 'Western': [55, 119], 'blotting': [56], 'was': [58, 79, 183, 211, 220], 'detect': [61, 82], 'RAS': [67], 'downstream': [70], 'pathways.\r\n\r\n\r\nResults\r\nAfter': [72], 'transfecting': [73], 'mimics,': [75], 'real-time': [76], 'quantitative': [77], 'PCR': [78], 'use': [80], '△Ct': [84], 'values': [85], 'blank': [88, 189, 241, 274], 'control': [89, 93, 190, 242, 246, 275, 280], 'group,': [90, 94, 98, 243, 247], 'negative': [92, 194, 245, 279], 'they': [100], '15.25±1.12,': [102], '15.92±0.98,': [103], '10.58±0.87,': [105], 'respectively,': [106], 'suggesting': [107], 'expression': [109, 129], 'level': [110], 'cells': [116, 152, 168, 289], 'increased': [117, 269], 'significantly.': [118], 'blot': [120], 'results': [121, 142], 'showed': [122, 146, 233], 'that': [123, 147, 202, 234], 'significantly': [126, 185, 270], 'inhibited': [127], 'levels': [130], 'RAS,': [132], 'MEK,': [133], 'ERK1/2,': [134], 'pERK1/2': [136], 'protein': [137], '(all': [138], 'P<0.05).': [139], 'The': [140, 174, 197, 213, 224, 259, 293], 'test': [141], 'MTT': [144], 'relative': [148], 'survival': [149, 176], 'rates': [150, 238], '72.28±6.52%,': [154], '61.86±5.79%,': [155], '59.38±5.97%,': [157], 'respectively': [158], 'at': [159, 221], '24,': [160], '48,': [161], '72': [163], 'h': [164], 'after': [165], 'being': [169], 'by': [171], 'mimics.': [173], 'rate': [177, 263], 'group': [182, 191, 195, 210, 252, 268, 276, 281], 'decreased': [184], 'compare': [186, 271], 'with': [187, 272], '(P<0.05).': [196], 'cycle': [199], 'analysis': [200], 'revealed': [201], 'G1/G0': [205, 222], 'phase': [206], '66.84%.': [212], 'induced': [216], 'block': [219], 'phase.': [223], 'detection': [225], 'annexin/propidium': [227], 'iodide': [228], '(Annexin': [229], 'V/PI)': [230], 'double': [231], 'staining': [232], '2.7±0.83%,': [254], '2.5±0.81%,': [255], '18.2±1.58%,': [257], 'respectively.': [258], '(P<0.05).\r\n\r\n\r\nConclusions\r\nmiR-15b': [282], 'can': [283], 'inhibit': [284], 'promote': [291], 'targeted': [294], 'therapy': [295], 'for': [298, 309], 'is': [302], 'expected': [303], 'become': [305], 'a': [306], 'new': [307], 'way': [308], 'treatment': [311], 'gliomas.\r\n\r\n\r\nKey': [313], 'words:': [314], '\r\nGlioma;\xa0Cell': [315], 'proliferation;\xa0Cell': [316], 'apoptosis;\xa0miR-15b': [317]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3031869021', 'counts_by_year': [], 'updated_date': '2024-12-07T06:24:25.784564', 'created_date': '2020-06-05'}