Title: Correlation between matrix metalloproteinase-9 and diabetic nephropathy
Abstract:Objective To observe the changes of the expression of metalloproteinase(MMP)-9 at kidney with the development of diabetic nephropathy(DN) in streptozotocin(STZ)-induced diabetic rats and to investigat...Objective To observe the changes of the expression of metalloproteinase(MMP)-9 at kidney with the development of diabetic nephropathy(DN) in streptozotocin(STZ)-induced diabetic rats and to investigate their correlation.Methods Sixteen female Wistar rats were used to induce diabetes mellitus by intraperitoneal injection of STZ(60 mg/kg).Immunohistochemistry was used to detect MMP-9 expressions in kidneys with image analysis system on the 4th and 8th weeks.Results In this experiment,the expression of MMP-9 in diabetic kidneys on the 4th and 8th weeks(8.2±0.9,3.9±0.6) were both significantly lower than that in normal control rats(15.6±73.4,16.2±3.1,P0.01),and the level on the at 8th week (3.9±0.6) was lower than that on the 4th week(8.2±0.9,P0.01).Conclusion The reduced expression of MMP-9 is one of the main reasons for impairing renal structure of DN.Read More
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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